SynthesisScientific reports2018
Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Effect of a Whole-Food Plant-Based Diet on Periodontal Parameters in Patients With Cardiovascular Risk Factors: A Secondary Sub-Analysis of a Randomized Clinical Trial.Journal of clinical periodontology · 2025Trial
- Integrative transcriptomic analysis identifies ACP5 and FBLN5 as candidate shared transcriptomic signatures between pulpitis and carotid plaque rupture.Scientific reports · 2026Article
- MORF4L1 regulation and its role in chromatin remodeling, DNA damage, cellular senescence, and cardiometabolic disease.Vascular pharmacology · 2026Review
- The oral-vascular axis: immune mechanisms linking periodontal dysbiosis to systemic vascular pathology.Frontiers in immunology · 2026Review
- Genetic susceptibility to oral and atherosclerotic cardiovascular diseases based on dental and heart SCORE studies.Scientific reports · 2025Article
- Trans-omics analyses identify the biochemical network of LPCAT1 associated with coronary artery disease.Biomarker research · 2025Article
- Article
- Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis-A synthesis of recent findings.Periodontology 2000 · 2025Review
- Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine.Human genomics · 2024Review
- Periodontal disease: A systemic condition.Periodontology 2000 · 2024Review
- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
- lncRNA CDKN2B-AS1 regulates collagen expression.Human genetics · 2024Article
- Association of cardiovascular health and periodontitis: a population-based study.BMC public health · 2024Article
- Absent in Melanoma 2 Gene Associated Periodontitis and Coronary Heart Disease.F1000Research · 2024Article
- Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease.JACC. Basic to translational science · 2023Article
- The correlation between periodontitis and uncontrolled hypertension is mediated by inflammatory markers: results from a cross-sectional study of urban elderly population in southeast China.BMC oral health · 2023Article
- Coronary atherosclerosis and periodontitis have similarities in their clinical presentation.Frontiers in oral health · 2023Article
- Unexpected Relationships: Periodontal Diseases: Atherosclerosis-Plaque Destabilization? From the Teeth to a Coronary Event.Biology · 2022Review
- Exome Sequencing of 5 Families with Severe Early-Onset Periodontitis.Journal of dental research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 12 institutions in 5 countries.
Matthias MunzCharité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany.ORCID 0000-0002-4728-3357
Gesa M RichterCharité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany.
Bruno G LoosDepartment of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Søren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
Kimon DivarisDepartment of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, USA.ORCID 0000-0003-1290-7251
Steven OffenbacherDepartment of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Birte HoltfreterUnit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-6541-3127
Thomas KocherUnit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Greifswald, Germany.
Corinna BruckmannDepartment of Conservative Dentistry and Periodontology, Medical University Vienna, School of Dentistry, Vienna, Austria.
Yvonne Jockel-SchneiderDepartment of Periodontology, Clinic of Preventive Dentistry and Periodontology, University Medical Center of the Julius-Maximilians-University, Würzburg, Germany.
Christian GraetzDepartment of Conservative Dentistry, Unit of Periodontology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Loreto MunozInstitute for Cardiogenetics, University of Lübeck, 23562, Lübeck, Germany.
Anita BhandariInstitute for Cardiogenetics, University of Lübeck, 23562, Lübeck, Germany.
Stephanie TennstedtInstitute for Cardiogenetics, University of Lübeck, 23562, Lübeck, Germany.
Ingmar StaufenbielDepartment of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, Hannover, Germany.
Nathalie van der VeldeDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Lisette C P G M de GrootWageningen University, Division of Human Nutrition, Wageningen, The Netherlands.ORCID 0000-0003-2778-2789
Jürgen WellmannInstitute of Epidemiology and Social Medicine, University Münster, Münster, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University Münster, Münster, Germany.
Bastian KroneInstitute of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID 0000-0002-6573-983X
Matthias LaudesDepartment of Medicine 1, University of Kiel, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology, Christian-Albrechts-University, Kiel, Germany.
Andre FrankeInstitute of Epidemiology, Christian-Albrechts-University, Kiel, Germany.ORCID 0000-0003-1530-5811
Henrik DommischCharité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany.
Jeanette ErdmannInstitute for Cardiogenetics, University of Lübeck, 23562, Lübeck, Germany.ORCID 0000-0002-4486-6231
Arne S SchaeferCharité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany. arne.schaefer@charite.de.ORCID 0000-0001-5816-6765
German Centre for Cardiovascular Research · DEHumboldt-Universität zu Berlin · DEChristian-Albrechts-Universität zu Kiel · DEUniversitätsmedizin Greifswald · DEErasmus MC · NLUniversity of Bonn · DEUniversity of North Carolina at Chapel Hill · USAcademic Center for Dentistry Amsterdam · NLInstitut für Medizinische Informatik, Biometrie und Epidemiologie · DEMedizinische Hochschule Hannover · DEUniversitätszahnklinik Wien · ATWageningen University & Research · NL
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) SCHA 1582/3-1
Abstract
Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (P
Indexed as
Aggressive PeriodontitisCase-Control StudiesCoronary Artery DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHumansPolymorphism, Single NucleotideRisk Factors
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