ArticleNature communications2018
Speed dependent descending control of freezing behavior in Drosophila melanogaster.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Hoverfly responses to looming stimuli depend on elevation and speed.The Journal of experimental biology · 2026Article
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- Genetic heterogeneity alleviates behavioral trade-off between exploration and vigilance iniScience · 2026Article
- Dynamic trajectory cues drive sequenced integration in approach detectors.bioRxiv : the preprint server for biology · 2026Article
- Contactless Acoustic Trapping of Hoverflies for Behavioral Studies.Annals of the New York Academy of Sciences · 2026Article
- Drosophila DNp03 descending neurons serve as a hub within a flight saccade network.Current biology : CB · 2026Article
- Nash equilibrium of attack and defense behaviors between predators and prey.PLoS computational biology · 2025Article
- Foot placement control underlies stable locomotion across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered reactivity to threatening stimuli ineLife · 2025Article
- Neurogenomic and behavioral principles shape freezing dynamics and synergistic performance in Drosophila melanogaster.Nature communications · 2025Article
- The visuomotor transformations underlying target-directed behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multifaceted and extensive behavioral trajectories of genomically diverse Drosophila lines.Scientific data · 2025Article
- Intermittent Vibration Induces Sleep via an Allatostatin A-GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Age-associated alteration of innate defensive response to a looming stimulus and brain functional connectivity pattern in mice.Scientific reports · 2024Article
- Looming stimuli reliably drive innate defensive responses in male rats, but not learned defensive responses.Scientific reports · 2024Article
- Article
- Descending control of motor sequences in Drosophila.Current opinion in neurobiology · 2024Review
- Article
- Automated behavioral analysis reveals that mice employ a bait-and-switch escape mechanism to de-escalate social conflict.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The most fundamental choice an animal has to make when it detects a threat is whether to freeze, reducing its chances of being noticed, or to flee to safety. Here we show that Drosophila melanogaster exposed to looming stimuli in a confined arena either freeze or flee. The probability of freezing versus fleeing is modulated by the fly's walking speed at the time of threat, demonstrating that freeze/flee decisions depend on behavioral state. We describe a pair of descending neurons crucially implicated in freezing. Genetic silencing of DNp09 descending neurons disrupts freezing yet does not prevent fleeing. Optogenetic activation of both DNp09 neurons induces running and freezing in a state-dependent manner. Our findings establish walking speed as a key factor in defensive response choices and reveal a pair of descending neurons as a critical component in the circuitry mediating selection and execution of freezing or fleeing behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.