ArticleThe EMBO journal2018
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.
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Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
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- Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice.Nature communications · 2022Article
- Intercellular Communication in the Central Nervous System as Deduced by Chemical Neuroanatomy and Quantitative Analysis of Images: Impact on Neuropharmacology.International journal of molecular sciences · 2022Review
- Female-specific role of ciliary neurotrophic factor in the medial amygdala in promoting stress responses.Neurobiology of stress · 2022Article
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- Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2021Article
- The role of trauma experiences, personality traits, and genotype in maintaining posttraumatic stress disorder symptoms among child survivors of the Wenchuan earthquake.BMC psychiatry · 2020Article
- The role of motile cilia in the development and physiology of the nervous system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Ciliary Neurotrophic Factor Acts on Distinctive Hypothalamic Arcuate Neurons and Promotes Leptin Entry Into and Action on the Mouse Hypothalamus.Frontiers in cellular neuroscience · 2020Article
- Secretagogin expression in the vertebrate brainstem with focus on the noradrenergic system and implications for Alzheimer's disease.Brain structure & function · 2019Article
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Authors and funding
29 authors at 9 institutions in 6 countries.
Alán AlpárSE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Semmelweis University, Budapest, Hungary alpar.alan@med.semmelweis-univ.hu tibor.harkany@meduniwien.ac.at.
Péter ZaholaSE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Semmelweis University, Budapest, Hungary.
János HanicsSE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Semmelweis University, Budapest, Hungary.
Zsófia HevesiSE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Semmelweis University, Budapest, Hungary.
Solomiia KorchynskaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Marco BeneventoDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Christian PiflDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Gergely ZacharDepartment of Anatomy, Histology, and Embryology, Semmelweis University, Budapest, Hungary.
Jessica PeruginiSection of Neuroscience and Cell Biology, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Ilenia SeveriSection of Neuroscience and Cell Biology, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Patrick LeitgebDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Joanne BakkerDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Andras G MiklosiDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Evgenii TretiakovImmanuel Kant Baltic Federal University, Kaliningrad, Russia.
Erik KeimpemaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Gloria ArqueDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Ramon O TasanDepartment of Pharmacology, Medical University Innsbruck, Innsbruck, Austria.
Günther SperkDepartment of Pharmacology, Medical University Innsbruck, Innsbruck, Austria.
Katarzyna MalenczykDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Zoltán MátéInstitute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
Ferenc ErdélyiInstitute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
Gábor SzabóInstitute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
Gert LubecParacelsus Medical University, Salzburg, Austria.
Miklós PalkovitsDepartment of Anatomy, Histology, and Embryology, Semmelweis University, Budapest, Hungary.
Antonio GiordanoSection of Neuroscience and Cell Biology, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Tomas Gm HökfeltDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Roman A RomanovDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Tamas L HorvathProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Departments of Comparative Medicine and Neuroscience, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria alpar.alan@med.semmelweis-univ.hu tibor.harkany@meduniwien.ac.at.ORCID 0000-0002-6637-5900
Medical University of Vienna · ATSemmelweis University · HUMarche Polytechnic University · ITHUN-REN Institute of Experimental Medicine · HUImmanuel Kant Baltic Federal University · RUInnsbruck Medical University · ATKarolinska Institutet · SEParacelsus Medical University · ATYale University · US
Funding
The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7MAustrian Science Fund FWF DOC 33Austrian Science Fund FWF P 29952European Research Council 695136NIA NIH HHS P01 AG051459
Abstract
Stress-induced cortical alertness is maintained by a heightened excitability of noradrenergic neurons innervating, notably, the prefrontal cortex. However, neither the signaling axis linking hypothalamic activation to delayed and lasting noradrenergic excitability nor the molecular cascade gating noradrenaline synthesis is defined. Here, we show that hypothalamic corticotropin-releasing hormone-releasing neurons innervate ependymal cells of the 3
Indexed as
Stress, PhysiologicalAdrenergic NeuronsAnimalsCiliary Neurotrophic FactorHypothalamusLocus CoeruleusMiceMice, KnockoutRatsCiliary Neurotrophic FactorCa2+‐sensor proteinhypothalamus–pituitary–adrenal axisneurotrophinpost‐traumatic stress disorderprefrontal cortex
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.