ArticleProceedings of the National Academy of Sciences of the United States of America2018
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.Nature reviews. Drug discovery · 2020Pooled it
- The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation.Genes & development · 2026Article
- PANoptosis in the pathogenesis of myelodysplastic syndromes.Molecular oncology · 2026Review
- Multi-omics elucidates the regulatory mechanisms of tryptophan in gut health of weaned piglets.Animal microbiome · 2026Article
- Global trends and mechanistic insights into A20 (TNFAIP3) in autoimmunity and inflammation.American journal of translational research · 2026Review
- Ubiquitin-Modifying Enzymes as Cell-Fate Regulators in Intestinal Inflammation.International journal of biological sciences · 2026Review
- Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease.The Journal of clinical investigation · 2025Article
- Pathological roles of ubiquitination and deubiquitination systems in sepsis-induced myocardial dysfunction.Biomolecules & biomedicine · 2025Review
- UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity.Cell death discovery · 2025Article
- The Role of A20 in Cancer: Friend or Foe?Cells · 2025Review
- MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives.Molecular oncology · 2025Review
- Deciphering Key Regulatory Roles of Linear Ubiquitination in Cell Fate Determination and Disease.Research (Washington, D.C.) · 2025Review
- Inorganic dietary nanoparticles in intestinal barrier function of inflammatory bowel disease: allies or adversaries?Frontiers in immunology · 2025Review
- RIPK1 signaling pathways: implications for autoimmune and neuroinflammatory diseases.Frontiers in immunology · 2025Review
- The mesenteric adipokine SFRP5 alleviated intestinal epithelial apoptosis improving barrier dysfunction in Crohn's disease.iScience · 2024Article
- Inhibition of NLRP3 inflammasome activation by A20 through modulation of NEK7.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A20 in Kidney Transplantation and Autoimmunity.International journal of molecular sciences · 2024Review
- Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.Inflammatory bowel diseases · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Ricard Garcia-CarbonellLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, CA 92093.
Jerry WongLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, CA 92093.
Ju Youn KimLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, CA 92093.
Lisa Abernathy CloseDepartment of Microbiology and Immunology, Indiana University School of Medicine, South Bend, IN 46617.
Brigid S BolandDepartment of Medicine, Division of Gastroenterology, University of California, San Diego, CA 92093.
Thomas L WongLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, CA 92093.
Philip A HarrisPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426.
Samuel B HoDepartment of Medicine, VA San Diego Healthcare System, San Diego, CA 92161.
Soumita DasDepartment of Pathology, University of California, San Diego, CA 92093.
Peter B ErnstDepartment of Pathology, University of California, San Diego, CA 92093.
Roman SasikCenter for Computational Biology, University of California, San Diego, CA 92093.
William J SandbornDepartment of Medicine, Division of Gastroenterology, University of California, San Diego, CA 92093.
John BertinPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426.
Pete J GoughPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426.
John T ChangDepartment of Medicine, Division of Gastroenterology, University of California, San Diego, CA 92093.
Michelle KelliherDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
David BooneDepartment of Microbiology and Immunology, Indiana University School of Medicine, South Bend, IN 46617.
Monica GumaLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, CA 92093; mguma@ucsd.edu karinoffice@ucsd.edu.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, CA 92093; mguma@ucsd.edu karinoffice@ucsd.edu.
University of California, San Diego · USGlaxoSmithKline (United States) · USIndiana University School of MedicineUniversitat Autònoma de Barcelona · ESUniversity of Massachusetts Chan Medical School · USVA San Diego Healthcare System · US
Funding
Tumor Assessment CoreP01CA128814 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, JEFFREY W · 2009 to 2020
$19.1MUC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4MREGULATION OF NFKB AND IKK BY PROINFLAMMATORY STIMULIR01AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL · 1998 to 2017
$7.4MRip Proteins in Innate Immune SignalingR01AI075118 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KELLIHER, MICHELLE ALICE · 2009 to 2024
$6.7MNF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of InflammationR37AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin · 2018 to 2026
$6.0MThe Role of the Adenosine Receptor in Th Cell Development and FunctionR01AI079145 · NIAID · UNIVERSITY OF VIRGINIA · PI ERNST, PETER B. · 2010 to 2022
$4.7MThe UCSD Digestive Diseases Research Development CenterR24DK080506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS · 2008 to 2012
$2.7MRole of atypical Protein Kinase C in Inflammatory Bowel DiseaseR01DK093507 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2012 to 2016
$1.7MCholine kinase: a novel target for rheumatoid arthritisK08AR064834 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUMA, MONICA · 2013 to 2017
$687kThe Role of Adenosine Receptors in Th Cell Development and FunctionR56AI079145 · NIAID · UNIVERSITY OF VIRGINIA · PI ERNST, PETER B. · 2008 to 2008
$378kCIHRNCATS NIH HHS KL2 TR001444NCI NIH HHS P01 CA128814NIAID NIH HHS R01 AI043477NIAID NIH HHS R01 AI075118NIAID NIH HHS R01 AI079145NIAID NIH HHS R37 AI043477NIAID NIH HHS R56 AI079145NIAMS NIH HHS K08 AR064834NIDDK NIH HHS R01 DK093507NIDDK NIH HHS R24 DK080506
Abstract
Intestinal epithelial cell (IEC) death is a common feature of inflammatory bowel disease (IBD) that triggers inflammation by compromising barrier integrity. In many patients with IBD, epithelial damage and inflammation are TNF-dependent. Elevated TNF production in IBD is accompanied by increased expression of the
Indexed as
ApoptosisAnimalsCaspase 3Caspase 8HumansInflammatory Bowel DiseasesIntestinal MucosaMiceMice, TransgenicNF-kappa BProtein MultimerizationReceptor-Interacting Protein Serine-Threonine KinasesTumor Necrosis Factor-alphaTumor Necrosis Factor alpha-Induced Protein 3CASP3 protein, humanCasp3 protein, mouseCASP8 protein, humanCasp8 protein, mouseCaspase 3Caspase 8NF-kappa BReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanRipk1 protein, mouseTNFAIP3 protein, humanTnfaip3 protein, mouseTumor Necrosis Factor-alphaTumor Necrosis Factor alpha-Induced Protein 3A20apoptosisinflammatory bowel diseaseintestinal epithelial cellsRIPK1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.