Evidence map›Paper›PMID 30209189›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants.

Shamus P Keeler, Eugene V Agapov, Michael E Hinojosa, Adam N Letvin, Kangyun Wu, Michael J Holtzman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 103 citations in OpenAlex.

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  18. Lung-resident lymphocytes and their roles in respiratory infections and chronic respiratory diseases.Chinese medical journal pulmonary and critical care medicine · 2024
    Review
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shamus P KeelerPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Eugene V AgapovPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Michael E HinojosaPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-5193-6699
Adam N LetvinPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Kangyun WuPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-8093-094X
Michael J HoltzmanPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110 mjholtzman@wustl.edu.
Washington University in St. Louis · US

Funding

The role of CARDS toxin in genesis and exacerbation of allergic inflammationU19AI070412 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BASEMAN, JOEL BARRY · 2006 to 2015
$19.7M
Tissue and Cell Processing CoreU19AI070489 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2006 to 2016
$17.9M
Preclinical Development of an Anti-Mucus DrugUH3HL123429 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2016 to 2018
$4.7M
PARP9-DTX3L Control Of Viral Infection and Airway DiseaseR01AI130591 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2017 to 2021
$3.0M
IL-33 AND EXCESS MUCUS PRODUCTIONR01HL121791 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2014 to 2017
$1.9M
INTERFERON SIGNAL ENHANCERS AS ANTIVIRAL THERAPEUTICSR01AI111605 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2014 to 2017
$1.8M
TREM2 AND AIRWAY DISEASER01HL120153 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2016 to 2018
$1.3M
NHLBI NIH HHS R01 HL120153NHLBI NIH HHS R01 HL121791NHLBI NIH HHS UH3 HL123429NIAID NIH HHS R01 AI111605NIAID NIH HHS R01 AI130591NIAID NIH HHS U19 AI070412NIAID NIH HHS U19 AI070489
6 · The paper itself

Abstract

Clinical and experimental observations suggest that chronic lung disease is linked to respiratory viral infection. However, the long-term aspect of this relationship is not yet defined using a virus that replicates at properly high levels in humans and a corresponding animal model. In this study, we show that influenza A virus infection achieves 1 × 10

Indexed as

AnimalsBronchiBronchial HyperreactivityCells, CulturedDisease Models, AnimalHumansInfluenza A virusInfluenza, HumanInterleukin-13Interleukin-17LungLung DiseasesMetaplasiaMiceMice, Inbred C57BLMice, KnockoutIl17a protein, mouseInterleukin-13Interleukin-17Muc5ac protein, mouseMucin 5ACRNA, ViralSTAT6 Transcription Factor

Identifiers

PMID30209189
PMCPMC6179922
OpenAlexW2891453115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.