Evidence map›Paper›PMID 30209170›Full record

ArticleJournal of virology2018

Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression.

Xiang Zheng, Jia Wang, Lingyu Wei, Qiu Peng, Yingxue Gao, Yuxin Fu, Yuanjun Lu, Zailong Qin, Xuemei Zhang, Jianhong Lu and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Article
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  12. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
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  15. Article
  16. Article
  17. Review
  18. Research advances in the molecular classification of gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  19. Review
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Xiang ZhengXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Jia WangXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Lingyu WeiXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Qiu PengXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Yingxue GaoXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Yuxin FuXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Yuanjun LuXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Zailong QinXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Xuemei ZhangXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Jianhong LuXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Chunlin OuXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Zhengshuo LiXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Xiaoyue ZhangXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Peishan LiuXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Wei XiongXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Guiyuan LiXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Qun YanXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China.
Jian MaXiangya Hospital, Cancer Research Institute, Central South University, Changsha, China majian@csu.edu.cn.ORCID 0000-0001-9395-0416
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is the first human virus found to encode many microRNAs. It is etiologically linked to nasopharyngeal carcinoma and EBV-associated gastric carcinoma. During the latent infection period, there are only a few EBV proteins expressed, whereas EBV microRNAs, such as the BamHI-A region rightward transcript (BART) microRNAs, are highly expressed. However, how these BART miRNAs precisely regulate the tumor growth in nasopharyngeal carcinoma and gastric carcinoma remains obscure. Here, we report that upregulation of EBV-miR-BART5-3p promotes the growth of nasopharyngeal carcinoma and gastric carcinoma cells. BART5-3p directly targets the tumor suppressor gene

Indexed as

Gene Expression Regulation, Neoplastic3' Untranslated RegionsAnimalsAntineoplastic AgentsApoptosisCell CycleDrug Resistance, NeoplasmEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansMaleMice, NudeMicroRNAsMiddle AgedNasopharyngeal Neoplasms3' Untranslated RegionsAntineoplastic AgentsMicroRNAsRNA, ViralTP53 protein, humanTumor Suppressor Protein p53Epstein-Barr virusgastric cancermiR-BART5-3pnasopharyngeal carcinomap53

Identifiers

PMID30209170
PMCPMC6232473
OpenAlexW2889793976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.