Evidence map›Paper›PMID 30209165›Full record

ArticleJournal of virology2018

Modulation of Vaccine-Induced CD4 T Cell Functional Profiles by Changes in Components of HIV Vaccine Regimens in Humans.

Franco Pissani, Bianca Schulte, Michael A Eller, Bruce T Schultz, Silvia Ratto-Kim, Mary Marovich, Prasert Thongcharoen, Somchai Sriplienchan, Supachai Rerks-Ngarm, Punnee Pitisuttithum and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Interleukin-21 in Viral Infections.International journal of molecular sciences · 2021
    Review
  3. Impact of TJournal of virology · 2020
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Franco Pissani *U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Bianca Schulte *Institute for HIV Research, University Hospital, University Duisburg-Essen, Essen, Germany.
Michael A EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Bruce T SchultzInstitute for HIV Research, University Hospital, University Duisburg-Essen, Essen, Germany.
Silvia Ratto-KimU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Mary MarovichU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Prasert ThongcharoenDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Somchai SriplienchanDepartment of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Supachai Rerks-NgarmDepartment of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
Punnee PitisuttithumVaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Stefan EsserHPSTD Clinic, University Hospital, University Duisburg-Essen, Essen, Germany.
Galit AlterMassachusetts General Hospital, Boston, Massachusetts, USA.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Jerome H KimU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Nelson L MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Hendrik StreeckU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA hendrik.streeck@uk-essen.de.ORCID 0000-0002-0335-6390
Henry M. Jackson Foundation · USUniversity of Duisburg-Essen · DEWalter Reed Army Institute of Research · USArmed Forces Research Institute of Medical Science · THMahidol University · THMassachusetts General Hospital · USMinistry of Public Health · THSiriraj Hospital · TH

Funding

Modulation of HIV-specific CD8+ T and B cell function by CD4+ T helper responsesR01AI091450 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STREECK, HENDRIK · 2010 to 2013
$1.7M
T follicular helper cells: Role in generation of anti-HIV antibody responsesR01AI094602 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STREECK, HENDRIK · 2011 to 2015
$1.6M
The Ohio State University Center for Clinical and Translational ScienceTL1TR001069 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$763k
NCATS NIH HHS TL1 TR001069NIAID NIH HHS R01 AI091450NIAID NIH HHS R01 AI094602
6 · The paper itself

Abstract

To date, six vaccine strategies have been evaluated in clinical trials for their efficacy at inducing protective immune responses against HIV infection. However, only the ALVAC-HIV/AIDSVAX B/E vaccine (RV144 trial) has demonstrated protection, albeit modestly (31%;

Indexed as

AIDS VaccinesAntibodies, NeutralizingCD8-Positive T-LymphocytesCells, CulturedHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansVaccinationAIDS VaccinesAntibodies, NeutralizingHIV AntibodiesHIV Envelope Protein gp120CD4 T cellsHIV vaccinehuman immunodeficiency virusRV144Tfh cells

Identifiers

PMID30209165
PMCPMC6232489
OpenAlexW2889666378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.