Evidence map›Paper›PMID 30209137›Full record

ArticleJournal of cell science2018

Reconstitution of immune cell interactions in free-standing membranes.

Edward Jenkins, Ana Mafalda Santos, Caitlin O'Brien-Ball, James H Felce, Martin J Wilcock, Deborah Hatherley, Michael L Dustin, Simon J Davis, Christian Eggeling, Erdinc Sezgin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Edward JenkinsMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Ana Mafalda SantosMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Caitlin O'Brien-BallMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
James H FelceKennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK.
Martin J WilcockMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Deborah HatherleyMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.ORCID 0000-0002-2684-1102
Michael L DustinKennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK.ORCID 0000-0003-4983-6389
Simon J DavisMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Christian EggelingMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Erdinc SezginMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK erdinc.sezgin@rdm.ox.ac.uk.ORCID 0000-0002-4915-388X

Funding

Medical Research Council G0902418Medical Research Council MC_UU_00008/4Medical Research Council MC_UU_00008/9Medical Research Council MC_UU_12010/4Medical Research Council MC_UU_12010/9Medical Research Council MR/K01577X/1Medical Research Council MR/M003051/1Wellcome Trust 207547/Z/17/Z
6 · The paper itself

Abstract

The spatiotemporal regulation of signalling proteins at the contacts formed between immune cells and their targets determines how and when immune responses begin and end. Therapeutic control of immune responses therefore relies on thorough elucidation of the molecular processes occurring at these interfaces. However, the detailed investigation of each component's contribution to the formation and regulation of the contact is hampered by the complexities of cell composition and architecture. Moreover, the transient nature of these interactions creates additional challenges, especially in the use of advanced imaging technology. One approach that circumvents these problems is to establish

Indexed as

Cell CommunicationCell MembraneHumansJurkat CellsPhosphatidylcholinesProtein BindingSignal TransductionUnilamellar LiposomesPhosphatidylcholinesUnilamellar LiposomesGiant unilamellar vesiclesImmune signallingImmune synapseIn vitro reconstitutionModel membranes

Identifiers

PMID30209137
PMCPMC6398472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.