Evidence map›Paper›PMID 30209131›Full record

ArticleThe Journal of biological chemistry2018

A cation-π interaction in a transmembrane helix of vacuolar ATPase retains the proton-transporting arginine in a hydrophobic environment.

Walter Hohlweg, Gabriel E Wagner, Harald F Hofbauer, Florian Sarkleti, Martina Setz, Nina Gubensäk, Sabine Lichtenegger, Salvatore Fabio Falsone, Heimo Wolinski, Simone Kosol and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Electric Forces and ATP Synthesis.Reviews of physiology, biochemistry and pharmacology · 2025
    Review
  3. Article
  4. Structural and Functional Diversity of Two ATP-Driven Plant Proton Pumps.International journal of molecular sciences · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Walter HohlwegFrom the Institutes of Chemistry and.
Gabriel E Wagnerthe Institute of Hygiene, Microbiology, and Environmental Medicine, Medical University of Graz, 8010 Graz, Austria.
Harald F Hofbauerthe Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, 8010 Graz, Austria.ORCID 0000-0003-2617-5901
Florian Sarkletithe Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, 8010 Graz, Austria.
Martina Setzthe Institute of Molecular Modeling and Simulation, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Nina GubensäkFrom the Institutes of Chemistry and.
Sabine Lichteneggerthe Institute of Hygiene, Microbiology, and Environmental Medicine, Medical University of Graz, 8010 Graz, Austria.
Salvatore Fabio FalsonePharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Heimo Wolinskithe Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, 8010 Graz, Austria.
Simone Kosolthe Department of Chemistry, University of Warwick, Gibbet Hill, Coventry CV4 7AL, United Kingdom.
Chris Oostenbrinkthe Institute of Molecular Modeling and Simulation, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Sepp D Kohlweinthe Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, 8010 Graz, Austria.
Klaus ZanggerFrom the Institutes of Chemistry and klaus.zangger@uni-graz.at.ORCID 0000-0003-1682-1594
University of Graz · ATBOKU University · ATMedical University of Graz · ATUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vacuolar ATPases are multisubunit protein complexes that are indispensable for acidification and pH homeostasis in a variety of physiological processes in all eukaryotic cells. An arginine residue (Arg

Indexed as

ProtonsArginineGene Knockout TechniquesHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationProtein Conformation, alpha-HelicalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStatic ElectricityTryptophanTyrosineVacuolar Proton-Translocating ATPasesArginineProtonsSaccharomyces cerevisiae ProteinsTryptophanTyrosineVacuolar Proton-Translocating ATPasesV-ATPase a subunit, S cerevisiaeATPasebiophysicsenzyme mechanismmembrane enzymemembrane transportmolecular dynamicsmolecular evolutionNMRSaccharomyces cerevisiaeyeast physiology

Identifiers

PMID30209131
PMCPMC6295739
OpenAlexW2891687141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.