Evidence map›Paper›PMID 30209128›Full record

ArticlemSphere2018

Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development.

Rachael L Hardison, Derek R Heimlich, Alistair Harrison, Wandy L Beatty, Sarah Rains, M Arthur Moseley, J Will Thompson, Sheryl S Justice, Kevin M Mason

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Exploiting haem-iron dependence of nontypeableFrontiers in cellular and infection microbiology · 2025
    Review
  3. Article
  4. Non-typeableEuropean respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  5. Immunomodulation as a Protective Strategy in Chronic Otitis Media.Frontiers in cellular and infection microbiology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rachael L HardisonCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-4624-1347
Derek R HeimlichCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Alistair HarrisonCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Wandy L BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sarah RainsDuke Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, USA.
M Arthur MoseleyDuke Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, USA.
J Will ThompsonDuke Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, USA.
Sheryl S JusticeCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA sheryl.justice@nationwidechildrens.org Kevin.Mason@nationwidechildrens.org.
Kevin M MasonCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA sheryl.justice@nationwidechildrens.org Kevin.Mason@nationwidechildrens.org.
Nationwide Children's Hospital · USDuke University · USWashington University in St. Louis · US

Funding

Disease severity of otitis media: Biofilms, invasion, and host responsesR01DC013313 · NIDCD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI JUSTICE, SHERYL S, MASON, KEVIN M · 2014 to 2018
$1.9M
NIDCD NIH HHS R01 DC013313
6 · The paper itself

Abstract

Nutrient limitation restricts bacterial growth in privileged sites such as the middle ear. Transient heme-iron restriction of nontypeable

Indexed as

AnimalsAnti-Bacterial AgentsBacterial ProteinsBiofilmsCell LineChinchillaCytoplasmDisease Models, AnimalEar, MiddleHaemophilus InfectionsHaemophilus influenzaeHemeHumansIronOtitis MediaPinocytosisAnti-Bacterial AgentsBacterial ProteinsHemeIronendolysosomal pathwayHaemophilushost cell invasionintracellular bacterial communitymacropinocytosisNTHInutritional immunity

Identifiers

PMID30209128
PMCPMC6135960
OpenAlexW2891920875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.