Evidence map›Paper›PMID 30209117›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2018

Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKα/β in the Normal Rectal Mucosa of Colorectal Adenoma Patients.

Rebecca Hodge, Hannah B Mandle, Stephen Ray, Sonia Tandon, Meaghan Peterson, Abigail Henry, Ferdous A Jahan, Roberd M Bostick, John A Baron, Elizabeth L Barry and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Effects of 1,25-Dihydroxy vitamin DMolecular and cellular biochemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Rebecca HodgeDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Hannah B MandleDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Stephen RayDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Sonia TandonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Meaghan PetersonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Abigail HenryDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Ferdous A JahanDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Roberd M BostickDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.ORCID 0000-0001-8626-4186
John A BaronDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Elizabeth L BarryDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Rami YacoubDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Robin E RutherfordDivision of Digestive Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
March E SeabrookConsultants in Gastroenterology, West Columbia, South Carolina.
Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. vfedirk@emory.edu.
Emory University · USDartmouth College · USSimulConsult · US

Funding

Colorectal Chemoprevention with Calcium and Vitamin DR01CA098286 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARON, JOHN ANTHONY · 2003 to 2015
$43.9M
Gut Microbiome, Antibiotic Use & Colon Cancer RecurrenceR01CA207467 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FEDIRKO, VERONIKA · 2017 to 2021
$2.5M
Calcium/Vitamin D, Biomarkers & Colon Polyp PreventionR01CA114456 · NCI · EMORY UNIVERSITY · PI BOSTICK, ROBERD MANER · 2006 to 2008
$1.3M
Calcium/Vitamin D, Biomarkers & Colon Polyp PreventionR56CA114456 · NCI · EMORY UNIVERSITY · PI BOSTICK, ROBERD MANER · 2009 to 2009
$474k
Vitamin D3, Calcium and Biomarkers of Gut Barrier FunctionR21CA182752 · NCI · EMORY UNIVERSITY · PI FEDIRKO, VERONIKA · 2014 to 2015
$389k
Vitamin D3, Calcium and Inflammation, Immunomodulation and Colonic PermeabilityR03CA184578 · NCI · EMORY UNIVERSITY · PI FEDIRKO, VERONIKA · 2014 to 2015
$171k
NCI NIH HHS R01 CA098286NCI NIH HHS R01 CA114456NCI NIH HHS R01 CA207467NCI NIH HHS R03 CA184578NCI NIH HHS R21 CA182752NCI NIH HHS R56 CA114456
6 · The paper itself

Abstract

Chronic inflammation in the colorectum, a significant contributor to colorectal carcinogenesis, can be triggered by the activation of proinflammatory signaling pathways such as those initiated by Toll-like receptors (TLR) and nuclear factor κB (NF-κB). Although experimental evidence supports calcium and vitamin D potentially modifying these proinflammatory pathways in the colorectum, human data in these regards are scarce. We investigated supplemental calcium (1,200 mg daily) and/or vitamin D

Indexed as

Dietary SupplementsAdenomaAgedBiomarkersBiopsyCalciumColorectal NeoplasmsFemaleFollow-Up StudiesGene Expression RegulationHumansI-kappa B KinaseIntestinal MucosaMaleMiddle AgedNeoplasm Recurrence, LocalBiomarkersCalciumI-kappa B KinaseToll-Like ReceptorsVitamin D

Identifiers

PMID30209117
PMCPMC6214739
OpenAlexW2891485013

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.