Evidence map›Paper›PMID 30209081›Full record

ArticleCancer discovery2018

Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.

Manon Eckhardt, Wei Zhang, Andrew M Gross, John Von Dollen, Jeffrey R Johnson, Kathleen E Franks-Skiba, Danielle L Swaney, Tasha L Johnson, Gwendolyn M Jang, Priya S Shah and 6 more

Open access · greenAbstract read
In one paragraph

Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Article
  3. Prevalence and prognostic impact of HPV, EBV, and HIV in head and neck squamous cell carcinoma in the Brazilian Amazon cohort.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Exploring treatment options in cancer: Tumor treatment strategies.Signal transduction and targeted therapy · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Neoantigens: promising targets for cancer therapy.Signal transduction and targeted therapy · 2023
    Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Manon Eckhardt *Quantitative Biosciences Institute (QBI), UCSF, San Francisco, California.
Wei Zhang *Department of Medicine, UCSD, La Jolla, California.ORCID 0000-0002-0942-1245
Andrew M GrossDepartment of Medicine, UCSD, La Jolla, California.
John Von DollenQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California.
Jeffrey R JohnsonQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California.ORCID 0000-0001-5221-2775
Kathleen E Franks-SkibaQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California.
Danielle L SwaneyQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California.ORCID 0000-0001-6119-6084
Tasha L JohnsonDepartment of Cellular and Molecular Pharmacology, UCSF, San Francisco, California.ORCID 0000-0001-5221-2775
Gwendolyn M JangQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California.
Priya S ShahQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California.
Toni M BrandDepartment of Otolaryngology-Head and Neck Surgery, UCSF, San Francisco, California.
Jacques ArchambaultDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-8107-3428
Jason F KreisbergDepartment of Medicine, UCSD, La Jolla, California.ORCID 0000-0002-3616-079X
Jennifer R GrandisThe Cancer Cell Map Initiative (CCMI), UCSF and UCSD, San Francisco and La Jolla, California.
Trey IdekerDepartment of Medicine, UCSD, La Jolla, California. nevan.krogan@ucsf.edu tideker@ucsd.edu.
Nevan J KroganQuantitative Biosciences Institute (QBI), UCSF, San Francisco, California. nevan.krogan@ucsf.edu tideker@ucsd.edu.
University of California, San Francisco · USGladstone Institutes · USNational Foundation for Cancer Research · USUniversity of California San Diego · USMcGill University · CA

Funding

X-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KROGAN, NEVAN J · 2007 to 2018
$48.8M
SYNTHETIC SYSTEMSP50GM085764 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2010 to 2018
$23.3M
Using Networks to Seed Hierarchical Whole-cell Models of CancerU54CA209891 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KROGAN, NEVAN J · 2017 to 2021
$10.9M
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Integrating genomics and the protein interactome for HPV+ head and neck cancer therapyR35CA231998 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2018 to 2024
$6.2M
NCI NIH HHS R35 CA231998NCI NIH HHS T32 CA108462NCI NIH HHS U54 CA209891NIGMS NIH HHS P50 GM082250NIGMS NIH HHS P50 GM085764
6 · The paper itself

Abstract

We have mapped a global network of virus-host protein interactions by purification of the complete set of human papillomavirus (HPV) proteins in multiple cell lines followed by mass spectrometry analysis. Integration of this map with tumor genome atlases shows that the virus targets human proteins frequently mutated in HPV

Indexed as

Host-Pathogen InteractionsBiomarkers, TumorCarcinogenesisCarcinoma, Squamous CellHead and Neck NeoplasmsHumansMutationPapillomaviridaePapillomavirus InfectionsProtein Interaction MapsBiomarkers, Tumor

Identifiers

PMID30209081
PMCPMC6375299
OpenAlexW2889744605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.