Evidence map›Paper›PMID 30209069›Full record

ArticleThe Journal of cell biology2018

The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip-coupling protein.

Aida Llauró, Hanako Hayashi, Megan E Bailey, Alex Wilson, Patryk Ludzia, Charles L Asbury, Bungo Akiyoshi

Open access · hybridAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons inFrontiers in cellular and infection microbiology · 2026
    Article
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  5. Article
  6. Article
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  8. Article
  9. Review
  10. Review
  11. Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution.Frontiers in cell and developmental biology · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Biomolecular NMR assignments · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Aida LlauróDepartment of Physiology and Biophysics, University of Washington, Seattle, WA.ORCID 0000-0001-9761-4268
Hanako HayashiDepartment of Biochemistry, University of Oxford, Oxford, UK.
Megan E BaileyDepartment of Physiology and Biophysics, University of Washington, Seattle, WA.
Alex WilsonDepartment of Biochemistry, University of Oxford, Oxford, UK.
Patryk LudziaDepartment of Biochemistry, University of Oxford, Oxford, UK.
Charles L AsburyDepartment of Physiology and Biophysics, University of Washington, Seattle, WA casbury@uw.edu.ORCID 0000-0002-0143-5394
Bungo AkiyoshiDepartment of Biochemistry, University of Oxford, Oxford, UK bungo.akiyoshi@bioch.ox.ac.uk.ORCID 0000-0001-6010-394X
University of Oxford · GBUniversity of Washington · US

Funding

Interdisciplinary Tranining in Cancer ResearchT32CA080416 · NCI · UNIVERSITY OF WASHINGTON · PI STODDARD, BARRY L. · 1998 to 2023
$9.7M
The Yeast Centrosome - Structure Assembly & FunctionP01GM105537 · NIGMS · UNIVERSITY OF COLORADO · PI DAVIS, TRISHA N. · 2014 to 2018
$8.3M
Reconstitution and biophysical study of chromosome segregation machineryR35GM134842 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury · 2020 to 2026
$4.7M
Supplement to Biophysical Study of Reconstituted Kinetochore-microtubule AttachmentsR01GM079373 · NIGMS · UNIVERSITY OF WASHINGTON · PI ASBURY, CHARLES · 2006 to 2019
$4.5M
Multicolor TIRF microscope for studying mitotic spindle components at the singleS10RR026406 · NCRR · UNIVERSITY OF WASHINGTON · PI ASBURY, CHARLES · 2010 to 2010
$214k
NCI NIH HHS T32 CA080416NCRR NIH HHS S10 RR026406NIGMS NIH HHS P01 GM105537NIGMS NIH HHS R01 GM079373NIGMS NIH HHS R35 GM134842Wellcome Trust 210622/Z/18/Z
6 · The paper itself

Abstract

Kinetochores are multiprotein machines that drive chromosome segregation by maintaining persistent, load-bearing linkages between chromosomes and dynamic microtubule tips. Kinetochores in commonly studied eukaryotes bind microtubules through widely conserved components like the Ndc80 complex. However, in evolutionarily divergent kinetoplastid species such as

Indexed as

Chromosome SegregationKinetochoresMicrotubulesProtozoan ProteinsTrypanosoma brucei bruceiProtozoan Proteins

Identifiers

PMID30209069
PMCPMC6219724
OpenAlexW2891869288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.