ArticleBMC endocrine disorders2018
Effect of mildly elevated thyroid-stimulating hormone during the first trimester on adverse pregnancy outcomes.
Article in BMC endocrine disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Global and Indian perspectives on trimester-specific reference intervals for thyroid hormones in pregnant women: a systematic review.Thyroid research · 2026Review
- Management of Hypothyroidism in Pregnancy and Its Impact on Maternal and Perinatal Outcomes: A Single-Center Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Pregnancy outcome in subclinical hypothyroidism with and without thyroid peroxidase antibodies-a prospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Effect of levothyroxine treatment on fetal growth among women with mild subclinical hypothyroidism and thyroid peroxidase antibody negative: a cohort study.BMC pregnancy and childbirth · 2023Article
- Relationship between Serum TSH Level and Adverse Pregnancy Outcome in Advanced Maternal Age.Journal of healthcare engineering · 2022Article
- High normal TSH is associated with lower mannan-binding lectin in women of childbearing age.BMC endocrine disorders · 2020Article
- Effects of Maternal Subclinical Hypothyroidism in Early Pregnancy Diagnosed by Different Criteria on Adverse Perinatal Outcomes in Chinese Women With Negative TPOAb.Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTo investigate the effect of a mildly elevated thyroid-stimulating hormone (TSH) concentration between 2.5 and 4.0 mIU/L during the first trimester on pregnancy outcomes in thyroid peroxydase antibody (TPOAb)-negative pregnant women.
methodsA total of 1858 pregnant women who were TPOAb-negative before 13
resultsAmong the 1858 study participants, the 97.5th percentile for TSH was 3.76 mIU/L, and 142 women (7.6%) had mildly elevated TSH levels between 2.5 and 4.0 mIU/L. No differences in the incidence of adverse pregnancy outcomes were observed between patients with a mildly elevated TSH level and those with a normal TSH level (< 2.5 mIU/L).
conclusionA mildly elevated TSH concentration (2.5-4.0 mIU/L) during the first trimester of pregnancy in TPOAb-negative women was not associated with adverse pregnancy outcomes in our study population. Accordingly, it may be possible to raise the upper limit of the healthy TSH reference range for pregnant women.
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Registered trials
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