ArticleThe Journal of international medical research2018
Positive correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy: a multicenter retrospective study.
Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Microvascular damage in diabetic nephropathy and the subsequent risk of Alzheimer's disease: a systematic review.Annals of medicine and surgery (2012) · 2026Article
- Diabetes and postoperative cognitive dysfunction and delirium in adults: mechanisms, biomarkers, and clinical management.Frontiers in endocrinology · 2026Review
- Altered static and dynamic effective connectivity in patients with type 2 diabetes mellitus with and without microvascular complications.European journal of medical research · 2025Article
- Risk Factors, Pathological Changes, and Potential Treatment of Diabetes-Associated Cognitive Dysfunction.Journal of diabetes · 2025Review
- Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes.Frontiers in endocrinology · 2025Review
- Crosstalk of kidney and brain in diabetes-related cognitive impairment and therapeutic strategies.Frontiers in endocrinology · 2025Review
- Global cognition and executive functions of older adults with type 1 diabetes mellitus without dementia.Journal of diabetes investigation · 2024Article
- Early use of SGLT2 inhibitors reduces the progression of diabetic kidney disease: a retrospective cohort study.American journal of translational research · 2024Article
- Potential effects of peripheral neuropathy on brain function in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Prevalence of cognitive impairment and its associated factors in type 2 diabetes mellitus patients with hypertension in Hunan, China: a cross-sectional study.Frontiers in psychiatry · 2024Article
- Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline.International journal of molecular sciences · 2022Review
- Expert Consensus on Cognitive Dysfunction in Diabetes.Current medical science · 2022Article
- Spatiotemporal Dynamics of Cerebral Vascular Permeability in Type 2 Diabetes-Related Cerebral Microangiopathy.Frontiers in endocrinology · 2021Article
- Altered Functional Topological Organization in Type-2 Diabetes Mellitus With and Without Microvascular Complications.Frontiers in neuroscience · 2021Article
- Spot Urine Albumin Creatinine Ratio can be a Predictor of Cognitive Function in Type 2 Diabetes Mellitus.Indian journal of nephrologyArticle
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was performed to explore the correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy (T2DN) by detecting changes in cognitive function and cerebral metabolism in these patients with different stages of T2DN.
methodsProspectively maintained databases were reviewed from 2006 to 2017. Blood biochemical indexes and the urinary albumin excretion rate (UAER) were measured in all participants. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA). Cognitive impairment was the primary endpoint. Renal microangiopathy was the secondary endpoint. Pearson correlation analysis was used to assess correlations.
resultsTwo hundred sixteen patients with type 2 diabetes mellitus (T2DM) were divided into three groups according to their UAER: T2DM without nephropathy (n=72), early T2DM with nephropathy (n=74), and the clinical stage of early T2DM with nephropathy (n=70). Healthy participants were selected as the normal control group (n=70). Pearson correlation analysis demonstrated that the total MMSE and MoCA score was negatively correlated with the UAER (r=-0.327) and positively correlated with the estimated glomerular filtration rate (r=0.428) in patients with T2DN.
conclusionsThe present study showed a positive correlation between cognitive impairment and renal microangiopathy in patients with T2DN.
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