ArticleCell reports2018
Overcoming the Cost of Positive Autoregulation by Accelerating the Response with a Coupled Negative Feedback.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Multiple input-multiple output (MIMO) designs in two-component signalling systems of Mycobacterium tuberculosis.FEMS microbiology reviews · 2026Review
- Threshold-dependent negative autoregulation of PIF4 gene expression optimizes growth and fitness in Arabidopsis.PLoS genetics · 2025Article
- Loss of LasR function leads to decreased repression ofJournal of bacteriology · 2025Article
- The proximal enhancer of the snail gene mediates negative autoregulatory feedback in Drosophila melanogaster.Genetics · 2025Article
- Computational inference of Rhizobium phaseoli transcriptional regulatory network predicts Transcription Factors involved in nodulation.Briefings in functional genomics · 2025Article
- Deciphering the intricate hierarchical gene regulatory network: unraveling multi-level regulation and modifications driving secondary cell wall formation.Horticulture research · 2024Article
- Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.PloS one · 2024Article
- Chemical Reaction Models in Synthetic Promoter Design in Bacteria.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling.Nature communications · 2023Article
- Article
- Genome-wide mapping of thebioRxiv : the preprint server for biology · 2023Article
- Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites.PLoS computational biology · 2022Article
- A balancing act in transcription regulation by response regulators: titration of transcription factor activity by decoy DNA binding sites.Nucleic acids research · 2021Article
- A portable library of phosphate-depletion based synthetic promoters for customable and automata control of gene expression in bacteria.Microbial biotechnology · 2021Article
- Role of a local transcription factor in governing cellular carbon/nitrogen homeostasis in Pseudomonas fluorescens.Nucleic acids research · 2021Article
- Overlaid positive and negative feedback loops shape dynamical properties of PhoPQ two-component system.PLoS computational biology · 2021Article
- Epistatic Effect of Regulators to the Adaptive Growth of Escherichia coli.Scientific reports · 2020Article
- Article
- The HSV-1 ICP4 Transcriptional Auto-Repression Circuit Functions as a Transcriptional "Accelerator" Circuit.Frontiers in cellular and infection microbiology · 2020Article
- Control of theEcoSal Plus · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A fundamental trade-off between rapid response and optimal expression of genes below cytotoxic levels exists for many signaling circuits, particularly for positively autoregulated systems with an inherent response delay. Here, we describe a regulatory scheme in the E. coli PhoB-PhoR two-component system, which overcomes the cost of positive feedback and achieves both fast and optimal steady-state response for maximal fitness across different environments. Quantitation of the cellular activities enables accurate modeling of the response dynamics to describe how requirements for optimal protein concentrations place limits on response speed. An observed fast response that exceeds the limit led to the prediction and discovery of a coupled negative autoregulation, which allows fast gene expression without increasing steady-state levels. We demonstrate the fitness advantages for the coupled feedbacks in both dynamic and stable environments. Such regulatory schemes offer great flexibility for accurate control of gene expression levels and dynamics upon environmental changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.