Evidence map›Paper›PMID 30208208›Full record

ArticleThe Laryngoscope2019

Does Delaying Endoscopic Sinus Surgery Adversely Impact Quality-of-Life Outcomes?

Jeremiah A Alt, Richard R Orlandi, Jess C Mace, Zachary M Soler, Timothy L Smith

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Timing of Surgery and Outcomes in Chronic Rhinosinusitis: A Narrative Review and Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Pooled it
  2. Article
  3. Article
  4. The value of endoscopic sinus surgery in chronic rhinosinusitis.Laryngoscope investigative otolaryngology · 2021
    Review
  5. Observational
  6. Review
  7. Article
  8. Long-term revision rates for endoscopic sinus surgery.International forum of allergy & rhinology · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeremiah A AltSinus and Skull Base Surgery Program, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah.
Richard R OrlandiSinus and Skull Base Surgery Program, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah.
Jess C MaceDivision of Rhinology and Sinus/Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland.
Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, U.S.A.
Timothy L SmithDivision of Rhinology and Sinus/Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland.

Funding

DETERMINANTS OF SURGICAL OUTCOMES IN CHRONIC SINUSITISR01DC005805 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SMITH, TIMOTHY L, SOLER, ZACHARY M · 2004 to 2020
$7.6M
University of Utah Center for clinical and Translational ScienceKL2TR001065 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$1.1M
A Novel Glycosaminoglycan-Based Therapeutic for Chronic RhinosinusitisR43AI126987 · NIAID · GLYCOMIRA, LLC · PI ALT, JEREMIAH ANDREW, PRESTWICH, GLENN DOWNES · 2016 to 2016
$298k
TERATOCARCINOMA STEM CELL ADHESIONK04CA001065 · NCI · WESLEYAN UNIVERSITY · PI GRABEL, LAURA B. · 1985 to 1989
–
National Center for Advancing Translational Sciences of the National Institute of Health KL2TR001065National Institute of Allergy and Infectious Diseases 1R43 AI126987NCATS NIH HHS KL2 TR001065NIAID NIH HHS R43 AI126987NIDCD NIH HHS R01 DC005805University of Utah Program in Personalized Health
6 · The paper itself

Abstract

objectivesThere is little consensus regarding the prognostic value of symptom duration in predicting clinical disease severity or quality-of-life (QOL) outcomes in patients with chronic rhinosinusitis (CRS). Our objectives were to: 1) determine if patients with longer symptom duration have worse preoperative disease severity and/or QOL, and 2) determine if delayed surgical intervention influences outcomes of endoscopic sinus surgery (ESS).

methodsPatients diagnosed with CRS were prospectively enrolled into a multicenter cohort study and observed 14.7 (standard deviaton {SD} ± 4.8) months on average following primary ESS. Preoperative symptom duration was stratified into short-term (< 12 months), middle-term (12-60 months), and long-term (> 60 months). Disease severity was assessed using endoscopy and computed tomography. Disease-specific QOL was measured with the 22-item Sinonasal Outcome Test (SNOT-22) and Rhinosinusitis Disability Index. Adjusted bivariate and multivariate associations between symptom duration, disease severity, and QOL scores were evaluated.

resultsOne hundred and thirteen patients met inclusion criteria with 35 patients lost to postoperative follow-up. No significant differences in preoperative disease severity or QOL scores were reported between symptom duration subgroups. Participants in the long-term symptom subgroup reported significantly greater mean postoperative improvement on SNOT-22 total scores (n = 28; -36.3[± 22.2]) compared to both short-term (n = 27; -23.4[SD ± 11.3]; P = 0.039) and middle-term (n = 23; -23.5[SD ± 20.1]; P = 0.050) subgroups. Postoperative QOL improvements in the long-term symptom subgroup remained significantly greater (P ≤ 0.036) after multivariate adjustment.

conclusionsSymptom duration was not associated with mean preoperative disease severity or QOL. Patients with long-term symptom duration reported the greatest mean postoperative QOL improvement, suggesting that delayed surgical intervention may not reduce QOL improvements following ESS. LEVEL OF EVIDENCE: 2c Laryngoscope, 129:303-311, 2019.

Indexed as

Quality of LifeTime-to-TreatmentComorbidityDemographyEndoscopyFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPrognosisProspective StudiesRhinitisSeverity of Illness IndexSinusitisTomography, X-Ray Computedchronic diseasepatient-reported outcome measuresQuality of lifesinusitissymptom assessment

Identifiers

PMID30208208
PMCPMC6344235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.