ArticlePloS one2018
Increased H. pylori stool shedding and EPIYA-D cagA alleles are associated with gastric cancer in an East Asian hospital.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Bad bugs mean business: gastric cancer is an intended consequence ofInfection and immunity · 2026Review
- Review
- Association between autoimmune thyroid disease and presence of CagA and gastric intestinal metaplasia among patients with H. pylori: a cross-sectional endoscopic study.BMC endocrine disorders · 2026Article
- The prevalence and risk factors ofMicrobiota in health and disease · 2024Article
- Single-cell Profiling Uncovers aCancer research communications · 2023Article
- Immunohistochemical Differentiation between Western and East Asian Types of CagA-PositiveCanadian journal of gastroenterology & hepatology · 2022Article
- EPIYA Motif Genetic Characterization fromAdvanced biomedical research · 2022Article
- Current and Emerging Applications of Droplet Digital PCR in Oncology: An Updated Review.Molecular diagnosis & therapy · 2022Review
- Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer.Applied microbiology and biotechnology · 2021Review
- SustainedLife science alliance · 2021Article
- Droplet Digital PCR-Based Detection of Clarithromycin Resistance in Helicobacter pylori Isolates Reveals Frequent Heteroresistance.Journal of clinical microbiology · 2018Article
- Review
- Diagnostic approach toAnnals of gastroenterologyReview
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHelicobacter pylori infection increases risk for gastric cancer. Geographic variation in gastric cancer risk has been attributed to variation in carriage and type of the H. pylori oncogene cagA. Colonization density may also influence disease and cagA has been associated with higher shedding in stool. However, the relationship between H. pylori load in the stool and in the stomach is not clear.
methodsTo investigate possible differences in H. pylori load in the stomach and shedding in stool, H. pylori load and cagA genotype were assessed using droplet digital PCR assays on gastric mucosa and stool samples from 49 urea breath test-positive individuals, including 25 gastric cancer and 24 non-cancer subjects at Henan Cancer Hospital, Henan, China.
resultsQuantitation of H. pylori DNA indicated similar gastric loads among cancer and non-cancer cases, but the gastric cancer group had a median H. pylori load in the stool that was six times higher than that of the non-cancer subjects. While the cagA gene was uniformly present among study subjects, only 70% had the East Asian cagA allele, which was significantly associated with gastric cancer (Fisher's Exact Test, p = 0.03).
conclusionH. pylori persists in a subset of gastric cancer cases and thus may contribute to cancer progression. In this East Asian population with a high prevalence of the cagA gene, the East Asian allele could still provide a marker for gastric cancer risk. IMPACT: This study contributes to our understanding of H. pylori dynamics in the context of pathological changes.
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