ArticleJournal of neurophysiology2018
Experience-related reductions of myelin and axon diameter in adulthood.
Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fiber calibre, and vascularization.GeroScience · 2026Article
- [Myelination as a modulating factor in memory circuitry].Revista de neurologia · 2023Review
- Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain.The European journal of neuroscience · 2022Article
- A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming.Nature communications · 2022Article
- Hebbian activity-dependent plasticity in white matter.Cell reports · 2022Article
- White matter diffusivity and its correlations to state measures of psychopathology in male refugees with posttraumatic stress disorder.NeuroImage. Clinical · 2022Article
- Reassessing associations between white matter and behaviour with multimodal microstructural imaging.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- White matter microstructural changes in short-term learning of a continuous visuomotor sequence.Brain structure & function · 2021Article
- White matter and neurological disorders.Archives of pharmacal research · 2020Review
- Changes in fundus reflectivity during myopia development in chickens.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239-8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.