ArticleJournal of oncology practice2018
Comorbidity Assessment in the National Cancer Database for Patients With Surgically Resected Breast, Colorectal, or Lung Cancer (AFT-01, -02, -03).
Article in Journal of oncology practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02171078 (Post-Treatment Surveillance in Breast Cancer), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post-Treatment Surveillance in Breast Cancer: Bringing Cost Effectiveness Research (CER) to the Alliance
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guideline for the Comprehensive Perioperative Management of Older Patients With Lung Cancer (2025).Journal of evidence-based medicine · 2026Guideline
- Pooled it
- Frailty and low utilization of curative-intent surgical resection in nonmetastatic pancreatic cancer.JNCI cancer spectrum · 2026Article
- Characteristics and Outcomes of Patients With Malignancies Prior to Colorectal Cancer: A Propensity Score Matched Analysis.Journal of gastrointestinal cancer · 2026Article
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- Sequence of therapy impact on older women with comorbidities and triple-negative or HER2-positive breast cancer.NPJ breast cancer · 2025Review
- Disease-specific survival outcomes for patients after locoregional treatment for ductal carcinoma in situ: observational cohort study.The British journal of surgery · 2024Observational
- Adjuvant Chemotherapy and Outcomes in Older Adult Patients With Biliary Tract Cancer.JAMA network open · 2024Article
- Is There a Role for Surgical Resection of Grade 3 Neuroendocrine Neoplasms?Annals of surgical oncology · 2022Article
- Lobectomy offers improved survival outcomes relative to segmentectomy for >2 but ≤4 cm non-small cell lung cancer tumors.JTCVS open · 2022Article
- Prognostic Value of Comorbidity for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy.Cancers · 2022Article
- Suboptimal therapy following breast conserving surgery in triple-negative and HER2-positive breast cancer patients.Breast cancer research and treatment · 2021Article
- Article
- Survival after palliative radiation therapy for cancer: The METSSS model.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- Article
- Association of Chemotherapy With Survival in Elderly Patients With Multiple Comorbidities and Estrogen Receptor-Positive, Node-Positive Breast Cancer.JAMA oncology · 2020Article
- Evaluation of the Use of Cancer Registry Data for Comparative Effectiveness Research.JAMA network open · 2020Article
- Important prognostic factors in leiomyosarcoma survival: a National Cancer Database (NCDB) analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Article
- Geriatric oncology health services research: Cancer and Aging Research Group infrastructure core.Journal of geriatric oncology · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeAccurate comorbidity measurement is critical for cancer research. We evaluated comorbidity assessment in the National Cancer Database (NCDB), which uses a code-based Charlson-Deyo Comorbidity Index (CCI), and compared its prognostic performance with a chart-based CCI and individual comorbidities in a national sample of patients with breast, colorectal, or lung cancer. PATIENTS AND
methodsThrough an NCDB Special Study, cancer registrars re-abstracted perioperative comorbidities for 11,243 patients with stage II to III breast cancer, 10,880 with stage I to III colorectal cancer, and 9,640 with stage I to III lung cancer treated with definitive surgical resection in 2006-2007. For each cancer type, we compared the prognostic performance of the NCDB code-based CCI (categorical: 0 or missing data, 1, 2+), Special Study chart-based CCI (continuous), and 18 individual comorbidities in three separate Cox proportional hazards models for postoperative 5-year overall survival.
resultsComorbidity was highest among patients with lung cancer (13.2% NCDB CCI 2+) and lowest among patients with breast cancer (2.8% NCDB CCI 2+). Agreement between the NCDB and Special Study CCI was highest for breast cancer (rank correlation, 0.50) and lowest for lung cancer (rank correlation, 0.40). The NCDB CCI underestimated comorbidity for 19.1%, 29.3%, and 36.2% of patients with breast, colorectal, and lung cancer, respectively. Within each cancer type, the prognostic performance of the NCDB CCI, Special Study CCI, and individual comorbidities to predict postoperative 5-year overall survival was similar.
conclusionThe NCDB underestimated comorbidity in patients with surgically resected breast, colorectal, or lung cancer, partly because the NCDB codes missing data as CCI 0. However, despite underestimation of comorbidity, the NCDB CCI was similar to the more complete measures of comorbidity in the Special Study in predicting overall survival.
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