Evidence map›Paper›PMID 30207835›Full record

ArticleCancer biology & therapy2019

Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-κB signals.

Hairong Huang, Lei Wei, Tao Qin, Nan Yang, Zhongdong Li, Zhiyun Xu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 5 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 5 syntheses or guidelines pooled it, 132 citations in OpenAlex.

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  11. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hairong Huanga Department of Cardiothoracic Surgery, Changhai Hospital , Second Military Medical University , Shanghai , China.
Lei Weia Department of Cardiothoracic Surgery, Changhai Hospital , Second Military Medical University , Shanghai , China.
Tao Qinb Department of Cardiothoracic Surgery, Jinling Hospital, Nanjing Clinical Medical College , Second Military Medical University , Nanjing , Jiangsu , China.
Nan Yangb Department of Cardiothoracic Surgery, Jinling Hospital, Nanjing Clinical Medical College , Second Military Medical University , Nanjing , Jiangsu , China.
Zhongdong Lib Department of Cardiothoracic Surgery, Jinling Hospital, Nanjing Clinical Medical College , Second Military Medical University , Nanjing , Jiangsu , China.
Zhiyun Xub Department of Cardiothoracic Surgery, Jinling Hospital, Nanjing Clinical Medical College , Second Military Medical University , Nanjing , Jiangsu , China.
Second Military Medical University · CNChanghai Hospital · CNNanjing General Hospital of Nanjing Military Command · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent and deadly cancers worldwide, especially in Eastern Asia. It has been indicated that circular RNAs (circRNA) are the key regulators in the development and progression of human cancers. We therefore evaluated the expression and regulation effects of ciRS-7 on the progression of ESCC, which is a recently identified circRNA and acts as a natural competing endogenous RNA. The expression of ciRS-7 was significantly increased in the ESCC tissues and cells as compared with their corresponding controls. In vitro study showed that ciRS-7 can promote the migration and invasion of ESCC cells. Over expression of miR-7, one of well-known targets of ciRS-7, can attenuate ciRS-7 induced invasion of ESCC cells and over expression of matrix metalloproteinase 2 (MMP2). The expression of stem cell marker Kruppel-like factor-4 (KLF-4), which has been reported as the target of miR7, increased significantly in ciRS-7 transfected ESCC cells. Knockdown of KLF-4 also attenuated over expression of ciRS-7 induced cell invasion. In addition, BAY 11-7082, the inhibitor of NF-κB, partially reversed ciRS-7 induced cell invasion. Mechanically studies indicated that ciRS-7 increased the expression of p65 via increasing the phosphorylation of IKK-α. Collectively, our present study revealed that ciRS-7 can trigger the migration and invasion of ESCC cells via miR-7/KLF4 and NF-κB signals. Targeted inhibition of ciRS-7 might be a potential approach for ESCC treatment.

Indexed as

Cell Line, TumorCell MovementEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagusFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMicroRNAsMiddle AgedNeoplasm InvasivenessNF-kappa B3-(4-methylphenylsulfonyl)-2-propenenitrileKLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription Factorslong non-coding RNA CDR1AS, humanMicroRNAsMIRN7-1 microRNA, humanNF-kappa BNitrilesRNA, CircularRNA, Long NoncodingSulfonesciRS-7ESCCKLF4miR-7NF-κB

Identifiers

PMID30207835
PMCPMC6343722
OpenAlexW2890303873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.