ArticleeLife2018
Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
What it found
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Initial researches on neuro-functional status and evolution in chronic ethanol consumers with recent traumatic spinal cord injury.Journal of medicine and lifePooled it
- Nyap1 Redirects JNK Signaling to Couple Neuroprotection with Circuit Regeneration After Spinal Cord Injury.Cellular and molecular neurobiology · 2026Article
- Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury.Cell reports. Medicine · 2025Article
- Thoracic Spinal Cord Contusion Impacts on Lumbar Enlargement: Molecular Insights.Molecular neurobiology · 2025Article
- Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury.iScience · 2024Article
- Spinal Cord Transcutaneous Stimulation in Cervical Spinal Cord Injury: A Review Examining Upper Extremity Neuromotor Control, Recovery Mechanisms, and Future Directions.Journal of neurotrauma · 2024Review
- Real-Time Analysis of Neuronal Cell Cultures for CNS Drug Discovery.Brain sciences · 2024Article
- Role of dendritic cells in spinal cord injury.CNS neuroscience & therapeutics · 2024Review
- Enhanced axon outgrowth of spinal motor neurons in co-culturing with dorsal root ganglions antagonizes the growth inhibitory environment.Regenerative therapy · 2024Article
- Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury.Bioactive materials · 2023Article
- Advances in molecular therapies for targeting pathophysiology in spinal cord injury.Expert opinion on therapeutic targets · 2023Review
- Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion.Experimental neurology · 2023Article
- The potential of gene therapies for spinal cord injury repair: a systematic review and meta-analysis of pre-clinical studies.Neural regeneration research · 2023Article
- RNA Sequencing and Spatial Transcriptomics in Traumatic Spinal Cord Injury (Review).Sovremennye tekhnologii v meditsine · 2023Review
- Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.Journal of molecular neuroscience : MN · 2022Article
- Elucidating the Pivotal Neuroimmunomodulation of Stem Cells in Spinal Cord Injury Repair.Stem cells international · 2021Review
- Neurotrophin-3 Promotes the Neuronal Differentiation of BMSCs and Improves Cognitive Function in a Rat Model of Alzheimer's Disease.Frontiers in cellular neuroscience · 2021Article
- Neurotrophin-3-mediated locomotor recovery: a novel therapeutic strategy targeting lumbar neural circuitry after spinal cord injury.Neural regeneration research · 2020Article
- Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury.Cell metabolism · 2020Article
- The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 2 countries.
Ying WangSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Wei WuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Xiangbing WuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Yan SunSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Yi P ZhangNorton Neuroscience Institute, Norton Healthcare, Louisville, United States.
Ling-Xiao DengSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Melissa Jane WalkerSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Wenrui QuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Chen ChenSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.ORCID http://orcid.org/0000-0001-5039-3066
Nai-Kui LiuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Qi HanSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Heqiao DaiSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.
Lisa Be ShieldsNorton Neuroscience Institute, Norton Healthcare, Louisville, United States.ORCID http://orcid.org/0000-0002-1526-4063
Christopher B ShieldsNorton Neuroscience Institute, Norton Healthcare, Louisville, United States.
Dale R SengelaubProgram in Neuroscience, Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States.
Kathryn J JonesDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, United States.
George M SmithShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, United States.
Xiao-Ming XuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States.ORCID http://orcid.org/0000-0002-7229-0081
Neurological Surgery · USNorton Healthcare · USFudan University · CNIndiana University School of MedicineMudanjiang Medical University · CNTemple University · US
Funding
Reprogramming reactive glial cells into functional new neurons after SCIR01NS111776 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WU, WEI, ZHANG, CHUN-LI · 2020 to 2024
$2.4MTargeting Multiple Kinases to Treat Experimental Spinal Cord Injury.R01NS100531 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIXBY, JOHN L, LEMMON, VANCE P · 2017 to 2021
$2.4MModulation of lumbar motor circuitry after an above-level SCI and NT-3 gene therapyR01NS103481 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI SMITH, GEORGE M, WU, WEI · 2017 to 2021
$1.9MRole of phospholipase A2 in spinal cord secondary injuryR01NS059622 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI XU, XIAO-MING · 2009 to 2013
$1.6MConstructing a growth-promoting pathway for functional regeneration after SCII01BX002356 · VA · RLR VA MEDICAL CENTER · PI BROWN, TODD J, JONES, KATHRYN JANE · 2015 to 2023
–Cardiolipin as a Novel Target for Neuroprotection after Spinal Cord InjuryI01BX003705 · VA · RLR VA MEDICAL CENTER · PI XU, XIAO-MING · 2018 to 2021
–BLRD VA I01 BX002356BLRD VA I01 BX003705CSRD VA I01 CX002356NIH HHS NS059622NIH HHS R01 NS100531NIH HHS R01 NS103481NINDS NIH HHS R01 NS059622NINDS NIH HHS R01 NS100531NINDS NIH HHS R01 NS103481NINDS NIH HHS R01 NS111776
Abstract
Retrogradely-transported neurotrophin signaling plays an important role in regulating neural circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to lumbar motoneurons (MNs) caudal to a thoracic (T10) contusive spinal cord injury (SCI) could modulate dendritic patterning and synapse formation of the lumbar MNs.
Indexed as
AnimalsCells, CulturedDendritesDependovirusFemaleMaleMice, Inbred C57BLMotor ActivityMotor NeuronsNeurotrophin 3Rats, Sprague-DawleyRecovery of FunctionSpinal CordSpinal Cord InjuriesSynaptic TransmissionThoracic VertebraeNeurotrophin 3dendritic morphologylumbar motoneuronmouseneuroscienceNT-3plasticityretrograde transportspinal cord injury
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.