ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Real-World Study of the Incidence, Risk Factors, and Prognostic Factors Associated with Bone Metastases in Women with Uterine Cervical Cancer Using Surveillance, Epidemiology, and End Results (SEER) Data Analysis.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Systematic review and meta analysis of the global incidence and clinicopathological characteristics of liver metastasis in patients with cervical cancer.Discover oncology · 2025Article
- Review of Bone Metastasis in Gynecologic Malignancies: Evaluation and Treatment.Current treatment options in oncology · 2025Review
- Bayesian Approaches in Exploring Gene-environment and Gene-gene Interactions: A Comprehensive Review.Cancer genomics & proteomics · 2023Review
- Factors associated with receipt of second-line recurrent or metastatic cervical cancer treatment in the United States: A retrospective administrative claims analysis.Gynecologic oncology reports · 2022Article
- Factors associated with receipt of second-line recurrent or metastatic cervical cancer treatment in the United States: A retrospective administrative claims analysis.Gynecologic oncology reports · 2022Article
- Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series.Diagnostics (Basel, Switzerland) · 2022Article
- A novel 14-gene signature for overall survival in lung adenocarcinoma based on the Bayesian hierarchical Cox proportional hazards model.Scientific reports · 2022Article
- Bone metastasis of esophageal carcinoma diagnosed as a first primary tumor: a population-based study.Translational cancer research · 2022Article
- Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients.Frontiers in medicine · 2022Article
- Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer.Bioengineered · 2021Article
- Clinical Characteristics, Treatment Modalities, and Potential Contributing and Prognostic Factors in Patients with Bone Metastases from Gynecological Cancers: A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
- Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study.BMC cancer · 2021Article
- An analysis of clinical values of MRI, CT and X-ray in differentiating benign and malignant bone metastases.American journal of translational research · 2021Article
- HighFrontiers in oncology · 2021Article
- MicroRNA Biomarkers of High-Grade Cervical Intraepithelial Neoplasia in Liquid Biopsy.BioMed research international · 2021Article
- Development and validation of a nomogram to predict synchronous lung metastases in patients with ovarian cancer: a large cohort study.Bioscience reports · 2020Article
- Ovarian, uterine, and cervical cancer patients with distant metastases at diagnosis: most common locations and outcomes.Clinical & experimental metastasis · 2020Article
- Small-Cell Carcinoma of the Uterine Cervix Discovered With Quadriplegia Caused by Cervical Spine Metastasis.Clinical medicine insights. Case reports · 2020Article
- Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study.Cancer management and research · 2020Article
- Bone Metastases Pattern in Newly Diagnosed Metastatic Nasopharyngeal Carcinoma: A Real-World Analysis in the SEER Database.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND The aims of this study were to investigate the incidence and risk factors for the development of bone metastases and prognosis in women with cancer of the uterine cervix using database analysis. MATERIAL AND METHODS The National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) database was analyzed for the incidence and survival rates of women diagnosed with uterine cervical cancer in the United States between 2010-2015. Multivariate logistic regression analysis identified risk factors for bone metastases. Kaplan-Meier analysis estimated the overall survival. Proportional hazard regression analysis estimated prognostic factors associated with bone metastases. RESULTS There were 19,363 women with uterine cervical cancer, and 469 women were diagnosed with bone metastases on initial diagnosis (2.42%). Increased T-stage, N-stage, non-squamous and non-adenocarcinoma histology, high-grade tumors, and the presence of lung, liver, and brain metastases were all significantly associated with early bone metastases. There were 364 patients with cervical cancer and bone metastases on initial diagnosis who were followed-up for at least one year. Multivariate Cox regression analysis showed that unmarried status and lung, liver, and brain metastases were significantly associated with reduced overall survival. No other significant risk or prognostic associations were found. CONCLUSIONS SEER data analysis showed that women with uterine cervical cancer had some standard risk factors associated with bone metastases, and with prognosis, but a heterogeneous group of risk factors was also present. The findings of this study may have clinical application in screening for bone metastases in women with cervical cancer.
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