ArticleMagnetic resonance in medicine2019
CEST MRI of 3-O-methyl-D-glucose uptake and accumulation in brain tumors.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Ultra-High-Field MRI in the Diagnosis and Management of Gliomas: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026Review
- Chemical exchange saturation transfer magnetic resonance imaging of the kidney: applications and challenges.Abdominal radiology (New York) · 2025Review
- Novel non‑metal‑based contrast agents for MR imaging: Emerging approaches and clinical perspectives (Review).International journal of oncology · 2025Review
- The proton resonance enhancement for CEST imaging and shift exchange (PRECISE) family of RF pulse shapes for CEST MRI.Magnetic resonance in medicine · 2025Article
- Effect of inhaled oxygen level on dynamic glucose-enhanced MRI in mouse brain.Magnetic resonance in medicine · 2024Article
- Metabolic brain imaging with glucosamine CEST MRI: in vivo characterization and first insights.Scientific reports · 2023Article
- Radiofrequency labeling strategies in chemical exchange saturation transfer MRI.NMR in biomedicine · 2023Review
- A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI: On the influence of head motion at 3T.Magnetic resonance in medicine · 2023Article
- Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Dysfunctional Glucose Metabolism in Alzheimer's Disease Onset and Potential Pharmacological Interventions.International journal of molecular sciences · 2022Review
- Dynamic contrast-enhanced CEST MRI using a low molecular weight dextran.NMR in biomedicine · 2022Article
- Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges.Pharmaceutics · 2022Review
- GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with[Molecular imaging and biology · 2022Article
- What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report.Magma (New York, N.Y.) · 2022Review
- Unlabeled aspirin as an activatable theranostic MRI agent for breast cancer.Theranostics · 2022Article
- In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3-O-Methyl-D-glucose in a murine tumor model.NMR in biomedicine · 2021Article
- Multimodality In Vivo Imaging of Perfusion and Glycolysis in a Rat Model of C6 Glioma.Molecular imaging and biology · 2021Article
- Accelerated multi-target chemical exchange saturation transfer magnetic resonance imaging of the mouse heart.Physics in medicine and biology · 2021Article
- Chemical exchange sensitive MRI of glucose uptake using xylose as a contrast agent.Magnetic resonance in medicine · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purpose3-O-Methyl-D-glucose (3-OMG) is a nonmetabolizable structural analog of glucose that offers potential to be used as a CEST-contrast agent for tumor detection. Here, we explore it for CEST-detection of malignant brain tumors and compare it with D-glucose.
methodsGlioma xenografts of a U87-MG cell line were implanted in five mice. Dynamic 3-OMG weighted images were collected using CEST-MRI at 11.7 T at a single offset of 1.2 ppm, showing the effect of accumulation of the contrast agent in the tumor, following an intravenous injection of 3-OMG (3 g/kg).
resultsTumor regions showed higher enhancement as compared to contralateral brain. The CEST contrast enhancement in the tumor region ranged from 2.5-5.0%, while it was 1.5-3.5% in contralateral brain. Previous D-glucose studies of the same tumor model showed an enhancement of 1.5-3.0% and 0.5-1.5% in tumor and contralateral brain, respectively. The signal gradually stabilized to a value that persisted for the length of the scan.
conclusions3-OMG shows a CEST contrast enhancement that is approximately twice as much as that of D-glucose for a similar tumor line. In view of its suggested low toxicity and transport properties across the BBB, 3-OMG provides an option to be used as a nonmetallic contrast agent for evaluating brain tumors.
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