Evidence map›Paper›PMID 30206811›Full record

ArticleJournal of the American Society for Mass Spectrometry2018

Detection of Neutral CO Lost During Ionic Dissociation Using Atmospheric Pressure Thermal Dissociation Mass Spectrometry (APTD-MS).

Pengyi Zhao, Travis White, R Graham Cooks, Qinghao Chen, Yong Liu, Hao Chen

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pengyi ZhaoDepartment of Chemistry and Biochemistry, Ohio University, Athens, OH, 45780, USA.
Travis WhiteDepartment of Chemistry and Biochemistry, Ohio University, Athens, OH, 45780, USA.
R Graham CooksDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA. cooks@purdue.edu.
Qinghao ChenDepartment of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ, 07065, USA. qinghao_chen@merck.com.
Yong LiuDepartment of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ, 07065, USA.
Hao ChenDepartment of Chemistry and Biochemistry, Ohio University, Athens, OH, 45780, USA. chenh2@ohio.edu.
Ohio University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPurdue University West Lafayette · US

Funding

Merck Research Laboratories New Technologies Review & Licensing Committee NT-RLCNational Science Foundation CHE-1455554National Science Foundation CHE-1709075
6 · The paper itself

Abstract

Elucidation of ion dissociation patterns is particularly important to structural analysis by mass spectrometry (MS). However, typically, only the charged fragments from an ion dissociation event are detected in tandem MS experiments; neutrals are not identified. In recent years, we have developed an atmospheric pressure thermal dissociation (APTD) technique that can be applied to dissociate ions at atmosphere pressure and thus provide one way to characterize neutral fragments. In this paper, we focus on the detection of neutral CO resulting from amino acid and peptide ion dissociation. In the first set of experiments, several protonated amino acids (e.g., + 1 ion of phenylalanine) were found to undergo loss of a neutral (s) of total mass 46 Da, a process leading to iminium ion formation. We successfully detected the neutral species CO by using a CO sensor, UV-Vis and MS analysis following selective CO trapping with a rhodium complex. The capture of CO from dissociation of protonated amino acids supports the assignment of the loss of 46 Da to neutral losses of CO and H

Indexed as

Carbon monoxide, peptide and amino acidMass spectrometryNeutral fragment detection

Identifiers

PMID30206811
OpenAlexW2891306627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.