ArticleJournal of endocrinological investigation2019
Adipose insulin resistance is associated with cardiovascular risk factors in polycystic ovary syndrome.
Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS.Frontiers in endocrinology · 2026Article
- Molecular and Immunomodulatory Mechanisms of Statins in Inflammation and Cancer Therapeutics with Emphasis on the NF-κB, NLRP3 Inflammasome, and Cytokine Regulatory Axes.International journal of molecular sciences · 2025Review
- Adipose tissue specific insulin resistance and prognosis of nondiabetic patients with ischemic stroke.Diabetology & metabolic syndrome · 2023Article
- Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults.Biology of sex differences · 2023Article
- Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression.Journal of clinical medicine · 2023Review
- Effect of aging on clinical features and metabolic complications of women with polycystic ovary syndrome.Journal of endocrinological investigation · 2021Article
- Metabolomics and inflammation in polycystic ovary syndrome.Journal of endocrinological investigation · 2020Article
- Unique Metabolic Features of Adults Discordant for Indices of Insulin Resistance.The Journal of clinical endocrinology and metabolism · 2020Article
- Clinical, hormonal and metabolic parameters in women with PCOS with different combined oral contraceptives (containing chlormadinone acetate versus drospirenone).Journal of endocrinological investigation · 2020Article
- Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids.Frontiers in endocrinology · 2020Review
- Relationship between surrogate estimates and direct measurement of insulin resistance in women with polycystic ovary syndrome.Journal of endocrinological investigation · 2019Article
- Renal resistive index in patients with polycystic ovary syndrome.Archives of endocrinology and metabolism · 2019Article
- TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe effects of adipose insulin resistance on cardiovascular risk factors in polycystic ovary syndrome (PCOS) remain largely unknown. We aimed to investigate associations between adipose insulin resistance and cardiovascular risk factors in PCOS.
methodsA total of 207 PCOS and 47 non-PCOS women were recruited from a large reproductive medicine center in this cross-sectional study. The PCOS diagnosis was based on the Rotterdam Criteria. The subjects received a standard oral glucose tolerance test. Adipose insulin resistance was evaluated using a validated index (adipose-IR = fasting insulin × free fatty acid concentrations).
resultsThe women with PCOS showed a higher adipose-IR index, and the adipose-IR index was tightly associated with the blood pressure, glucose and lipid parameters. A total of 98.0% of the women with PCOS in the highest adipose-IR quartile showed cardiovascular risk factors (obesity, hypertension, glucose intolerance or dyslipidemia), and this percentage was significantly higher than the percentage of those in the lowest quartile (32.7%). In addition, the percentages of women with three (31.4%) and four (13.7%) cardiovascular risk factors were significantly elevated in the highest adipose-IR quartile. The multivariable logistic regression analysis indicated that each 1-SD increment in the adipose-IR index resulted in higher risks of obesity (OR = 3.18, 95% CI = 2.12-4.76), hypertension (OR = 1.89, 95% CI = 1.31-2.73), glucose intolerance (OR = 2.45, 95% CI = 1.73-3.48), and dyslipidemia (OR = 2.18, 95% CI = 1.57-3.01). The C-reactive protein (CRP) level was positively associated with the adipose-IR index in women with PCOS (r = 0.45, P < 0.001).
conclusionsThe adipose-IR index was associated with cardiovascular risk factors in women with PCOS. Chronic inflammation may induce insulin resistance in the adipose tissue of women with PCOS.
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Registered trials
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