ReviewJournal of assisted reproduction and genetics2018
Paternal factors contributing to embryo quality.
Review in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 190 citations in OpenAlex.
- Qualitative and quantitative assessment of sperm miRNAs identifies hsa-miR-9-3p, hsa-miR-30b-5p and hsa-miR-122-5p as potential biomarkers of male infertility and sperm quality.Reproductive biology and endocrinology : RB&E · 2022Pooled it
- Quasi-randomized pilot clinical trial comparing the use of annexin columns in patients with abnormal sperm FISH undergoing IVF techniques.Scientific reports · 2025Trial
- A large retrospective study on 1PN embryo transfer supports the need for updated harmonized best practice guidelines.Human reproduction (Oxford, England) · 2026Article
- Sperm Imprinted Gene Methylation and DNA Fragmentation in ICSI Outcomes: A Pilot Study.Epigenomes · 2026Article
- SPACA4 regulates the structure and molecular basis of spermatid maturation and ultimately affects sperm quality in mice.Asian journal of andrology · 2026Article
- The role of sperm DNA fragmentation testing in predicting IVF and PGT-A outcomes.Scientific reports · 2026Article
- Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort.Environment & health (Washington, D.C.) · 2026Article
- Clinical Implications of Paternal Age in Assisted Reproduction: Integrating Sperm Epigenetic Evidence.Journal of clinical medicine · 2026Review
- The spermatozoon neck role in infertility and intracytoplasmic sperm injection outcomes.Journal of assisted reproduction and genetics · 2026Review
- Exploring determinants of cumulative live birth rates in IVF: insights from the EELI study in Lebanon.Reproductive health · 2026Article
- Flow Cytometric Assessment of Sperm DNA Fragmentation by TUNEL and Acridine Orange: Methodological and Clinical Insights.Journal of clinical medicine · 2026Article
- Impact of sperm fractionation on chromosome positioning, chromatin integrity, DNA methylation, and hydroxymethylation level.Cellular & molecular biology letters · 2025Article
- Male infertility.Systems biology in reproductive medicine · 2025Review
- Impact of chromosomal polymorphisms on pregnancy outcomes after in vitro fertilization or intracytoplasmic sperm injection: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Does Developmental Timing Matter? Comparative Analysis of Day 5 and Day 6 Euploid Blastocyst Transfers in Recurrent Implantation Failure Patients.Biomedicines · 2025Article
- Chromosomal Roadblocks in Male Fertility: Mechanisms, Risk Factors and Syndromes.Medicina (Kaunas, Lithuania) · 2025Review
- The Individual Variations in Sperm Quality of High-Fertility Boars Impact the Offspring Production and Early Physiological Functions.Veterinary sciences · 2025Article
- Porcine sperm bind to an oviduct glycan coupled to glass surfaces as a model of sperm interaction with the oviduct.Scientific reports · 2025Article
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Phthalates disrupt female reproductive health: a call for enhanced investigation into mixtures.Reproduction (Cambridge, England) · 2025Review
- The effect of male factors on embryo morphokinetics: a retrospective analysis of 2726 blastocysts.Journal of assisted reproduction and genetics · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeAdvancing maternal and paternal age leads to a decrease in fertility, and hence, many infertile couples opt for assisted reproductive technologies [ART] to achieve biological parenthood. One of the key determinants of achieving a live outcome of ART, embryo quality, depends on both the quality of the oocyte and sperm that have created the embryo. Several studies have explored the effect of oocyte parameters on embryo quality, but the effects of sperm quality on the embryo have not been comprehensively evaluated.
methodIn this review, we assess the effect of various genetic factors of paternal origin on the quality and development of the embryo.
resultsThe effects of sperm aneuploidy, sperm chromatin structure, deoxyribonucleic acid [DNA] fragmentation, role of protamines and histones, sperm epigenetic profile, and Y chromosome microdeletions were explored and found to negatively affect embryo quality.
conclusionWe propose that careful assessment of spermatozoal parameters is essential to achieve embryo development and a healthy live birth. However, the heterogeneity in test results and the different approaches of assessing a single sperm parameter highlight the need for more research and the development of standardized protocols to assess the role of sperm factors affecting embryo quality.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.