ReviewJournal of industrial microbiology & biotechnology2018
A comprehensive catalogue of polyketide synthase gene clusters in lichenizing fungi.
Review in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Deciphering the biosynthetic pathways of lichen acids.The New phytologist · 2026Article
- Functional redundancy and stability support the resilience of the Evernia prunastri holobiont under urbanization.Environmental microbiome · 2026Article
- Polyketide synthase gene clusters in the ericoid mycorrhizal fungusFrontiers in plant science · 2026Article
- A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont.Environmental microbiology · 2025Article
- Article
- Article
- Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them.Antibiotics (Basel, Switzerland) · 2022Review
- Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens.Frontiers in fungal biology · 2022Article
- Deletion of a Rare Fungal PKS CgPKS11 Promotes Chaetoglobosin A Biosynthesis, Yet Defers the Growth and Development ofJournal of fungi (Basel, Switzerland) · 2021Article
- Microbial Communities ofMicroorganisms · 2021Article
- The Architecture of Metabolism Maximizes Biosynthetic Diversity in the Largest Class of Fungi.Molecular biology and evolution · 2020Article
- Review
- What Is in Umbilicaria pustulata? A Metagenomic Approach to Reconstruct the Holo-Genome of a Lichen.Genome biology and evolution · 2020Article
- IMA Genome - F13: Draft genome sequences ofIMA fungus · 2020Article
- The Mosaic Architecture of NRPS-PKS in the Arbuscular Mycorrhizal FungusFrontiers in microbiology · 2020Article
- Biosynthetic Gene Content of the 'Perfume Lichens'Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lichens are fungi that form symbiotic partnerships with algae. Although lichens produce diverse polyketides, difficulties in establishing and maintaining lichen cultures have prohibited detailed studies of their biosynthetic pathways. Creative, albeit non-definitive, methods have been developed to assign function to biosynthetic gene clusters in lieu of techniques such as gene knockout and heterologous expressions that are commonly applied to easily cultivatable organisms. We review a total of 81 completely sequenced polyketide synthase (PKS) genes from lichenizing fungi, comprising to our best efforts all complete and reported PKS genes in lichenizing fungi to date. This review provides an overview of the approaches used to locate and sequence PKS genes in lichen genomes, current approaches to assign function to lichen PKS gene clusters, and what polyketides are proposed to be biosynthesized by these PKS. We conclude with remarks on prospects for genomics-based natural products discovery in lichens. We hope that this review will serve as a guide to ongoing research efforts on polyketide biosynthesis in lichenizing fungi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.