ArticleNeuroradiology2018
Percutaneous ozone nucleolysis for lumbar disc herniation.
Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of ozone with steroid injection therapy in lumbar disc herniation: meta-analysis.Frontiers in medicine · 2026Pooled it
- Gas therapy: an innovative application for intervertebral disc degeneration.Medical gas research · 2026Review
- Computed tomography-guided oxygen-ozone injection for the treatment of lumbar disc herniation complicated with lumbar spinal stenosis.Medical gas research · 2026Article
- Clinical Effectiveness of Intradiscal Ozone Therapy with or Without Periforaminal Steroid Injection in Lumbar Disc Herniation: Revisiting an Underutilized Treatment.Journal of orthopaedic case reports · 2026Article
- How Safe Are Oxygen-Ozone Therapy Procedures for Spine Disc Herniation? The SIOOT Protocols for Treating Spine Disorders.Journal of imaging · 2025Article
- Sex life and low back pain: The impact of intradiscal ozone therapy in patients with herniated lumbar disc.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- How Effective is Ozone Therapy in Treatment of Lumbar Disc Disease: a Systematic Review of Prospective Studies.Maedica · 2024Article
- Medical Ozone as a Therapeutic Option in Musculoskeletal Pain Control: A Critical Review of Clinical Trials Considering Safety and Quality Indicators for Procedures and Devices.The Yale journal of biology and medicine · 2024Review
- Image-Guided Minimally Invasive Treatment Options for Degenerative Lumbar Spine Disease: A Practical Overview of Current Possibilities.Diagnostics (Basel, Switzerland) · 2024Review
- Ozone therapy for skin diseases: Cellular and molecular mechanisms.International wound journal · 2023Review
- Ultrasound-Guided Interventions for Carpal Tunnel Syndrome: A Systematic Review and Meta-Analyses.Diagnostics (Basel, Switzerland) · 2023Review
- The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study.Frontiers in neurology · 2023Article
- Treatment of Intervertebral Disc Degeneration.Orthopaedic surgery · 2022Review
- COVID-19 and low back pain: previous infections lengthen recovery time after intradiscal ozone therapy in patients with herniated lumbar disc.La Radiologia medica · 2022Article
- Intradiscal ozone therapy: fluoroscopic guidance reduces operative time in comparison with CT guidance in patients with lumbar disc herniation.La Radiologia medica · 2022Article
- Article
- Percutaneous cervical coblation as therapeutic technique in the treatment of algo-dysfunctional pain of discal herniation.La Radiologia medica · 2021Observational
- Expert consensus of Chinese Association for the Study of Pain on the application of ozone therapy in pain medicine.World journal of clinical cases · 2021Review
- Metanalysis on the effectiveness of low back pain treatment with oxygen-ozone mixture: Comparison between image-guided and non-image-guided injection techniques.European journal of radiology open · 2021Review
- Ozone therapy for musculoskeletal disorders Current concepts.Acta bio-medica : Atenei Parmensis · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAll percutaneous minimally invasive disc treatments are typically indicated to contained disc herniations. Our study's aim is to evaluate prospectively the efficacy of ozone nucleolysis in the treatment of either contained or uncontained lumbar disc herniations.
methodsFifty-two patients, aged 27-87 years, with symptomatic herniated lumbar discs, without migration, sequestration, or severe degenerative disc changes, who failed conservative treatment, were included in our study. The patients underwent fluoroscopic-guided intradiscal oxygen-ozone mixture injection (5 ml) at a concentration of 27-30 μg/ml and periradicular injection of the same O
resultsOur initial results obtained at 2-month control were promising, indicating a significant decrease in pain disability and intensity in 74% (37) and 76% (38) of the patients respectively, and minimally increased to 76% (38) and 78% (39) at 6-month control (P < 0.001 and CI 99.9%). The mean preprocedure ODI and pain intensity scores were 35 ± 14.36 and 2.38 ± 0.90, respectively, which were reduced to 19.36 ± 13.12 and 1.04 ± 0.92 at 6-month control. Our failure had been mostly related to long symptoms duration of more than 1 year. No complications were recorded.
conclusionOzone nucleolysis is a safe cost-effective minimally invasive technique for treatment of contained and uncontained lumbar disc herniations.
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