Evidence map›Paper›PMID 30206545›Full record

ArticleTomography (Ann Arbor, Mich.)2018

Characterization of an Orthotopic Rat Model of Glioblastoma Using Multiparametric Magnetic Resonance Imaging and Bioluminescence Imaging.

Trung N T Le, Heeseung Lim, Amanda M Hamilton, Katie M Parkins, Yuanxin Chen, Timothy J Scholl, John A Ronald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Trung N T LeDepartment of Medical Biophysics, Western University, London, ON, Canada.
Heeseung LimDepartment of Medical Biophysics, Western University, London, ON, Canada.
Amanda M HamiltonRobarts Research Institute, Western University, London, ON, Canada.
Katie M ParkinsDepartment of Medical Biophysics, Western University, London, ON, Canada.
Yuanxin ChenRobarts Research Institute, Western University, London, ON, Canada.
Timothy J SchollDepartment of Medical Biophysics, Western University, London, ON, Canada.
John A RonaldDepartment of Medical Biophysics, Western University, London, ON, Canada.
Robarts Clinical Trials · CAWestern University · CALawson Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most common primary brain tumor, with most patients dying within 15-18 months of diagnosis despite aggressive therapy. Preclinical GBM models are valuable for exploring GBM progression and for evaluating new therapeutics or imaging approaches. The rat C6 glioma model shares similarities with human GBM, and application of noninvasive imaging enables better study of disease progression. Here, multiparametric magnetic resonance imaging (mpMRI) and bioluminescence imaging (BLI) were applied to characterize longitudinal development of orthotopic luciferase-expressing C6 tumors. Across all rats (

Indexed as

bioluminescence imagingC6 glioma ratglioblastoma multiformemagnetic resonance imagingorthotopic

Identifiers

PMID30206545
PMCPMC6127346
OpenAlexW2772042753

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.