ArticleEye (London, England)2019
Identifying the predictors of needling after XEN gel implant.
Article in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Comparison of XEN gel stent for management of open-angle glaucoma: a systematic review and meta-analysis.PeerJ · 2026Pooled it
- The efficacy of XEN gel stent implantation in glaucoma: a systematic review and meta-analysis.BMC ophthalmology · 2022Pooled it
- Update on XEN Gel Stent: A Narrative Review on Indications, Surgical Technique, and Postoperative Management.Ophthalmology and therapy · 2026Review
- Endophthalmitis in XEN45 Gel Stent: Case report and review of the literature.SAGE open medical case reports · 2026Article
- XEN‑45 implantation for refractory secondary glaucoma.BMC ophthalmology · 2025Article
- Update on Surgical Techniques Best Practices to Optimize Outcomes Following Gel Stent Implantation.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Two-Year Results of XEN Gel Stent Implantation for Pseudoexfoliative Glaucoma in Phakic versus Pseudophakic Eyes.Journal of clinical medicine · 2024Article
- Long-term efficacy and safety of XEN-45 gel stent implantation in patients with normal-tension glaucoma.BMC ophthalmology · 2024Article
- XEN45 Implant in Medically Controlled vs. Uncontrolled Eyes-Differential IOP Changes in Real-Life Conditions.Journal of clinical medicine · 2024Article
- Minimally Invasive Glaucoma Surgery: A Review of the Literature.Vision (Basel, Switzerland) · 2023Review
- Impact of Primary Needling on the XEN Implant Clinical Outcomes: A Real-Life Retrospective Study.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Multicenter case series of standalone XEN implant vs. combination with phacoemulsification in Turkish patients.International ophthalmology · 2021Article
- Two-year outcomes of minimally invasive XEN Gel Stent implantation in primary open-angle and pseudoexfoliation glaucoma.Acta ophthalmologica · 2021Observational
- XEN45 Gel Stent implantation in eyes with primary open angle glaucoma: A study from a single hospital in Taiwan.Journal of the Chinese Medical Association : JCMA · 2021Article
- Article
- XENClinical ophthalmology (Auckland, N.Z.) · 2020Review
- Recommendations for the management of elevated intraocular pressure due to bleb fibrosis after XEN gel stent implantation.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Optical coherence tomography-guided early postoperative management of XEN Gel implant.Taiwan journal of ophthalmologyArticle
- A comparison of iStent combined with phacoemulsification and endocyclophotocoagulation (ICE2) with the PreserFlo MicroShunt and XEN-45 implants.Therapeutic advances in ophthalmologyArticle
- Two-year Outcomes of XEN Implantation with Minimal Bleb Needling.Journal of current glaucoma practiceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify factors associated with probability of needling after XEN implant.
methodsAnalysis of data from prospective case series of patients with standalone XEN implant or combined XEN + cataract. Primary outcome was to determine whether postoperative day 1 and week 1 intraocular pressure (IOP), type of glaucoma, and glaucoma severity affected probability and number of needling interventions required.
resultsA total of 149 eyes of 113 patients were included in the analysis. In the XEN alone group, mean IOP at day 1 and week 1 was 9.70 ± 5.43 and 10.33 ± 4.41 mmHg, respectively. Eyes with lower IOP on day 1 were less likely to require needling (Odds ratio; OR, 1.14; 95% CI, 1.02-1.28; p = 0.02). A similar association (OR, 1.15; 95% CI, 1.06-1.26; p = 0.001) was observed between day 1 IOP in and number of needling interventions. In the XEN + cataract group, mean IOPs at day 1 and week 1 were 13.75 ± 7.52 and 11.81 ± 5.36 mmHg, respectively. No significant association was noted between early postoperative IOP and probability or number of needling in this group. With IOP > 20 mmHg the probability of needling was ~ 80%. This number decreased to 35% if day 1 IOP was < 10 mmHg.
conclusionPostoperative day 1 IOP is a predictor for needling in patients undergoing standalone XEN implantation. These results suggest that surgeons should not wait too long to intervene via needling if IOP in the early postoperative period is in the high teens or above. Type or severity of glaucoma did not influence the probability of needling or number of needling interventions required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.