ArticleScientific reports2018
Exploration of serum sensitive biomarkers of fatty liver in dairy cows.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Association between body condition score and abdominal fat assessed by ultrasound in Jersey cows.Veterinary medicine and science · 2024Article
- Serum macroelements and microelements levels in periparturient dairy cows in relation to fatty liver diseases.BMC veterinary research · 2024Article
- Clinical predictive significance of biomarker molecules elevation during the transition period in cattle suffering from different pathological states: A review.Open veterinary journal · 2024Review
- Article
- Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows.Metabolites · 2022Review
- The crucial role of lysine in the hepatic metabolism of growing Holstein dairy heifers as revealed by LC-MS-based untargeted metabolomics.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance.Journal of animal science and biotechnology · 2021Review
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Authors and funding
4 authors at 3 institutions in 3 countries.
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Abstract
Serum proteins are sensitive with diseases in dairy cows, and some of them could be used as biomarkers for fatty liver. This study aimed to explore serum biomarkers for fatty liver in dairy cows. A total of 28 early lactating dairy cows were chosen from a commercial dairy herds, liver samples were collected for determining concentration of triacylglycerol (TAG), and serum samples were collected for measuring fibroblast growth factor-21 (FGF-21), adiponectin, Lipoprotein-associated phospholipase A2 (LP-PLA2), and hemoglobin (Hb). Dairy cows were divided into fatty liver (liver TAG > 5%, wet weight) and control group (liver TAG < 5%, wet weight). Concentration of FGF-21 was greater in fatty liver cows, while the concentration of LP-PLA2 and Hb was less. The concentration of FGF-21 and total Hb had strong correlation with the liver TAG as well as good prediction power (kappa value = 0.79 and 0.58, respectively). These results suggested that the serum concentration of FGF-21 and total Hb could be potentially used as fatty liver biomarkers in lactating dairy cows.
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