Trial reportJournal of perinatology : official journal of the California Perinatal Association2018
Does fluid restriction improve outcomes in infants with hypoxic ischemic encephalopathy? A pilot randomized controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Post-Asphyxial Aftercare and Management of Neonates in Low- and Middle-Income Countries: A Systematic Evidence Synthesis.Neonatology · 2025Pooled it
- Neonatal encephalopathy: a systematic review of reported treatment outcomes.BMJ paediatrics open · 2024Pooled it
- Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Association between early hyponatremia and neurological diagnoses in infants with perinatal asphyxia.European journal of pediatrics · 2026Article
- Therapeutic Hypothermia Treatment for an Infant with Hypoxic-Ischemic Encephalopathy and Gastroschisis: A Case Report.AJP reports · 2023Article
- Perinatal asphyxia and hypothermic treatment from the endocrine perspective.Frontiers in endocrinology · 2023Review
- Need for more evidence in the prevention and management of perinatal asphyxia and neonatal encephalopathy in low and middle-income countries: A call for action.Seminars in fetal & neonatal medicine · 2021Review
- Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2021Observational
- Management of Multi Organ Dysfunction in Neonatal Encephalopathy.Frontiers in pediatrics · 2020Review
- Fluid restriction in moderate and severe hypoxemic-ischemic encephalopathy: more evidence is needed.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Response to Jogender Kumar DM.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate whether a strategy of restricted fluid intake in the first 4 days reduces mortality and morbidity among term neonates with moderate to severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. STUDY
designEighty neonates with HIE were randomized between January 2016 and February 2018 to receive normal fluid intake (n = 40) or restricted fluid intake (two-third of normal intake; n = 40) in the first 4 days of life. The primary outcome was a composite of death or major neurodevelopmental disability at 6 months of age.
resultsThe primary outcome occurred in 10 infants (26%) in the fluid-restricted group and 3 infants (8%) in the normal fluid intake group, but the difference was not statistically significant (p = 0.065). Five infants in the fluid-restricted group had hypoglycemia (p = 0.055).
conclusionRestricted fluid intake did not reduce the composite outcome of death or neurodevelopmental disability and was associated with a trend toward more hypoglycemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.