ArticleScientific reports2018
Investigation of hindbrain activity during active locomotion reveals inhibitory neurons involved in sensorimotor processing.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- CaMPARI2 enables stimulus-locked whole-brain activity mapping at cellular resolution in unrestrained larval zebrafish.Frontiers in molecular neuroscience · 2026Article
- CaMPARI2 Enables Stimulus-Locked Whole-Brain Activity Mapping at Cellular Resolution in Unrestrained Larval Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Uncovering multiscale structure in the variability of larval zebrafish navigation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice.Nature communications · 2024Article
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- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Granger causality analysis for calcium transients in neuronal networks, challenges and improvements.eLife · 2023Article
- Brainstem neural mechanisms controlling locomotion with special reference to basal vertebrates.Frontiers in neural circuits · 2023Review
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- Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.Molecular psychiatry · 2022Article
- Audiovisual integration in the Mauthner cell enhances escape probability and reduces response latency.Scientific reports · 2022Article
- BonZeb: open-source, modular software tools for high-resolution zebrafish tracking and analysis.Scientific reports · 2021Article
- Why Firing Rate Distributions Are Important for Understanding Spinal Central Pattern Generators.Frontiers in human neuroscience · 2021Article
- Noninvasive Multielectrode Array for Brain and Spinal Cord Local Field Potential Recordings from Live Zebrafish Larvae.Zebrafish · 2020Article
- Neuromodulatory Selection of Motor Neuron Recruitment Patterns in a Visuomotor Behavior Increases Speed.Current biology : CB · 2020Article
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- A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish.Biomedicines · 2019Article
- Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model.Journal of developmental biology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Locomotion in vertebrates relies on motor circuits in the spinal cord receiving inputs from the hindbrain to execute motor commands while dynamically integrating proprioceptive sensory feedback. The spatial organization of the neuronal networks driving locomotion in the hindbrain and role of inhibition has not been extensively investigated. Here, we mapped neuronal activity with single-cell resolution in the hindbrain of restrained transgenic Tg(HuC:GCaMP5G) zebrafish larvae swimming in response to whole-field visual motion. We combined large-scale population calcium imaging in the hindbrain with simultaneous high-speed recording of the moving tail in animals where specific markers label glycinergic inhibitory neurons. We identified cells whose activity preferentially correlates with the visual stimulus or motor activity and used brain registration to compare data across individual larvae. We then morphed calcium imaging data onto the zebrafish brain atlas to compare with known transgenic markers. We report cells localized in the cerebellum whose activity is shut off by the onset of the visual stimulus, suggesting these cells may be constitutively active and silenced during sensorimotor processing. Finally, we discover that the activity of a medial stripe of glycinergic neurons in the domain of expression of the transcription factor engrailed1b is highly correlated with the onset of locomotion. Our efforts provide a high-resolution, open-access dataset for the community by comparing our functional map of the hindbrain to existing open-access atlases and enabling further investigation of this population's role in locomotion.
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Registered trials
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