ArticleScientific reports2018
Bacillus velezensis A2 fermentation exerts a protective effect on renal injury induced by Zearalenone in mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Zearalenone Promotes Hepatic Stellate Cell Activation and Early Profibrotic Tendency in the Liver.Biomolecules · 2026Article
- β-Carboline alkaloid harmaline alleviates hyperuricemia-mediated renal inflammation by suppressing oxidative stress.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Timosaponin AIII mitigates zearalenone-induced kidney injury in weaned piglets in association with TLR/MAPK signaling suppression.Frontiers in veterinary science · 2026Article
- Aloe-emodin attenuates hyperuricemia-induced renal injury in mice by mitigating inflammation and oxidative stress.Frontiers in nutrition · 2025Article
- Innovative probiotic fermentation approach for zearalenone detoxification in dried distiller's grains.Frontiers in microbiology · 2025Article
- Dietary administration of Bacillus subtilis improves the health parameters and regulates the gene expression in mice receiving zearalenone-contaminated diet.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Bacillus velezensis CL197: a zearalenone detoxifying strain isolated from wheat with potential to be used in animal production.Veterinary research communications · 2024Article
- A Novel Bacillus Velezensis for Efficient Degradation of Zearalenone.Foods (Basel, Switzerland) · 2024Article
- A ProbioticToxins · 2023Article
- Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress.BMC molecular and cell biology · 2023Article
- Article
- Effect of Bining decoction on gouty nephropathy: a network pharmacology analysis and preliminary validation of gut microbiota in a mouse model.Annals of translational medicine · 2022Article
- The impact of Zearalenone on heat-stressed skeletal muscle in pigs.Journal of animal science · 2022Article
- Does probiotic Kefir reduce dyslipidemia, hematological disorders and oxidative stress induced by zearalenone toxicity in wistar rats?Toxicon: X · 2022Article
- Article
- The Extract ofFrontiers in pharmacology · 2021Article
- Pharmacological Basis for Use of a Novel Compound in Hyperuricemia: Anti-Hyperuricemic and Anti-Inflammatory Effects.Frontiers in pharmacology · 2021Article
- Complete Genome Sequence of Zearalenone Degrading Bacteria Bacillus velezensis A2.Current microbiology · 2021Article
- Article
- Molecular Insights of Copper Sulfate Exposure-Induced Nephrotoxicity: Involvement of Oxidative and Endoplasmic Reticulum Stress Pathways.Biomolecules · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zearalenone (ZEN) is an estrogen-like mycotoxin occurring in food and feeds, and it can cause oxidative damage and apoptosis in the testis, liver, and kidney. A current concern for researchers is how to reduce the harm it causes to humans and animals. In this study, our aim was to isolate and identify a novel and efficient ZEN-detoxifying strain of bacteria, and we aimed to assess the protective effect of the isolated strain on kidney damage caused by ZEN in mice. Our results indicated that a strain of Bacillus velezensis (B. velezensis), named A2, could completely degrade ZEN (7.45 μg/mL) after three days of incubation at 37 °C in the Luria-Bertani (LB) medium. This fermentation broth of the B. velezensis A2 strain was given to mice. The histopathological analysis indicated that the fermentation broth from the B. velezensis A2 strain reduced the degree of renal injury that is induced by ZEN. Furthermore, it greatly reduced the increase in serum levels of creatinine (CRE), uric acid (UA), and urea nitrogen (BUN) caused by ZEN. In addition, B. velezensis A2 strain also significantly inhibited the increase of malonaldehyde (MDA) content, and reversed the decreases of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities caused by ZEN. Studies have shown that ZEN is involved in the regulation of mRNA and protein levels of genes involved in the ER stress-induced apoptotic pathway, such as heavy chain binding protein (BIP), C-/-EBP homologous protein (CHOP), cysteine Aspartate-specific protease-12 (Caspase-12), c-Jun N-terminal kinase (JNK), and BCL2-related X protein (Bcl-2 and Bax). However, when mice were administered the fermentation broth of the B. velezensis A2 strain, it significantly reversed the expressions of these genes in their kidney tissue. In conclusion, our results indicate that the newly identified strain of B. velezensis A2, has a protective effect from renal injury induced by ZEN in mice. This strain has a potential application in the detoxification of ZEN in feed and protects animals from ZEN poisoning.
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