Evidence map›Paper›PMID 30206278›Full record

ArticleScientific reports2018

Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.

Caroline J Shaw, Ian Rivens, John Civale, Kimberley J Botting, Gail Ter Haar, Dino A Giussani, Christoph C Lees

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Early-onset twin-twin transfusion syndrome: Case series and systematic review.Australasian journal of ultrasound in medicine · 2019
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Caroline J ShawDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Ian RivensJoint Department of Physics, Institute of Cancer Research, Sutton, London, SM2 5NG, UK.
John CivaleJoint Department of Physics, Institute of Cancer Research, Sutton, London, SM2 5NG, UK.
Kimberley J BottingDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Gail Ter HaarJoint Department of Physics, Institute of Cancer Research, Sutton, London, SM2 5NG, UK.
Dino A GiussaniDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.ORCID 0000-0002-1308-1204
Christoph C LeesInstitute of Reproductive and Developmental Biology, Imperial College London, London, W12 0HS, UK. Christoph.lees@nhs.net.ORCID 0000-0002-2104-5561
Institute of Cancer Research · GBUniversity of Cambridge · GBImperial College London · GB

Funding

British Heart FoundationCancer Research UK 16464
6 · The paper itself

Abstract

Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through the uterus. However, further development of the technique to overcome the technical challenges of targeting and occluding blood vessels through intact skin remains essential to translation into human studies. So too does the assessment of fetal wellbeing following this procedure, and demonstration of the persistence of vascular occlusion. At 115 ± 10 d gestational age (term~147 days) 12 pregnant sheep were exposed to HIFU (n = 6), or to a sham (n = 6) therapy through intact abdominal skin (1.66 MHz, 5 s duration, in situ I

Indexed as

High-Intensity Focused Ultrasound AblationAnimalsBlood Flow VelocityBlood VesselsDisease Models, AnimalFemaleFetusHemorrhageHumansMiddle Cerebral ArteryPlacentaPregnancySheepUltrasonography, PrenatalUmbilical ArteriesUterus

Identifiers

PMID30206278
PMCPMC6134117
OpenAlexW2892005051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.