Evidence map›Paper›PMID 30206267›Full record

Trial reportScientific reports2018

Tranexamic acid in primary total knee arthroplasty without tourniquet: a randomized, controlled trial of oral versus intravenous versus topical administration.

Duan Wang, Hao-Yang Wang, Chang Cao, Ling-Li Li, Wei-Kun Meng, Fu-Xing Pei, De-Hua Li, Zong-Ke Zhou, Wei-Nan Zeng

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 8 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 8 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Duan WangDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, P.R. China.
Hao-Yang WangDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, P.R. China.
Chang CaoDepartment of Cosmetic Plastic and Burns surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
Ling-Li LiDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, P.R. China.
Wei-Kun MengDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, P.R. China.
Fu-Xing PeiDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, P.R. China.
De-Hua LiKey laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, 610041, P.R. China. 562372162@qq.com.
Zong-Ke ZhouDepartment of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, P.R. China. zongkehx@163.com.ORCID 0000-0002-0649-7076
Wei-Nan ZengCenter for Joint Surgery, Southwest Hospital, Third Military Medical University, 30# Gaotanyan Street, Chongqing, 400038, P.R. China. weinanzeng@163.com.
Sichuan University · CNArmy Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abundant literature confirms that intravenous (IV) and intra-articular (IA) administration of tranexamic acid (TXA) reduces blood loss in total knee arthroplasty (TKA). Oral formulations of TXA exhibit profound cost-saving benefits. However, comparisons of the clinical efficacy among three different modalities of TXA administration have not been previously investigated in the setting of TKA with no closed suction drain and tourniquet. A total of 180 patients undergoing TKA were randomized to receive 2-g oral TXA 2 hours preoperatively, 20-mg/kg IV TXA 5 minutes prior to incision, or 2-g IA TXA. The primary outcome was 72-hour blood loss. Secondary outcomes were reductions in hemoglobin, the rate of transfusions, and adverse events. No significant differences were identified with regard to the mean 72-hour blood loss among the three groups (1003 mL in oral group, 1108 mL in IV group, and 1059 mL in IA group, respectively). Similarly, hemoglobin reduction was equivalent among the groups. Only one patient in IV group exhibited deep venous thrombosis. No difference was identified regarding transfusion rates. Oral TXA results in similar blood loss in TKA, with a profound cost-saving benefit, compared with the IA and IV formulations.

Indexed as

Arthroplasty, Replacement, KneeAdministration, IntravenousAdministration, OralAgedAntifibrinolytic AgentsArthritis, RheumatoidBlood Loss, SurgicalBlood TransfusionFemaleHemoglobinsHumansInjections, Intra-ArticularKnee JointMaleMiddle AgedPostoperative HemorrhageAntifibrinolytic AgentsHemoglobinsTranexamic Acid

Identifiers

PMID30206267
PMCPMC6134001
OpenAlexW2891225666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.