ArticleScientific reports2018
Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Examining the predictive accuracy of metabolomics for small-for-gestational-age babies: a systematic review.BMJ open · 2019Pooled it
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Associations of maternal dietary patterns during pregnancy with neonatal obesity among Han and Tibetan maternal-child pairs: results from a prospective birth cohort in Tibetan area.European journal of nutrition · 2026Article
- Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation.Antioxidants (Basel, Switzerland) · 2026Article
- Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models.Islets · 2025Article
- AMPK: Accumulating Evidence in Support of its role in Dual Regulation of Vascular Function and Metabolism During Human Pregnancy.Acta physiologica (Oxford, England) · 2025Review
- Fetal growth and congenital heart disease at high altitude.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion.The Journal of experimental medicine · 2025Article
- Review
- Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Accelerated Longitudinal Weight Gain Among Infants With In Utero COVID-19 Exposure.The Journal of clinical endocrinology and metabolism · 2023Article
- Maternal asthma in relation to infant size and body composition.The journal of allergy and clinical immunology. Global · 2023Article
- High altitude differentially modulates potassium channel-evoked vasodilatation in pregnant human myometrial arteries.The Journal of physiology · 2022Article
- Review
- Why is human uterine artery blood flow during pregnancy so high?American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Maternal and Fetal PI3K-p110α Deficiency Induces Sex-Specific Changes in Conceptus Growth and Placental Mitochondrial Bioenergetic Reserve in Mice.Veterinary sciences · 2022Article
- Hypoxia ameliorates maternal diet-induced insulin resistance during pregnancy while having a detrimental effect on the placenta.Physiological reports · 2022Article
- Effects of hypoxic conditions during the plateau period on pre- and posthatch broiler performance.Poultry science · 2022Article
- Higher hemoglobin levels are an independent risk factor for gestational diabetes.Scientific reports · 2022Article
- Acute hypoxia induced dysregulation of clock-controlled ovary functions.Frontiers in physiology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Hypoxia of residence at high altitude (>2500 m) decreases birth weight. Lower birth weight associates with infant mortality and morbidity and increased susceptibility to later-in-life cardiovascular and metabolic diseases. We sought to determine the effects of hypoxia on maternal glucose and lipid metabolism and their contributions to fetal weight. C57BL6/NCrl mice, housed throughout gestation in normobaric hypoxia (15% oxygen) or normoxia, were studied at mid (E9.5) or late gestation (E17.5). Fetal weight at E17.5 was 7% lower under hypoxia than normoxia. The hypoxic compared with normoxic dams had ~20% less gonadal white adipose tissue at mid and late gestation. The hypoxic dams had better glucose tolerance and insulin sensitivity compared with normoxic dams and failed to develop insulin resistance in late gestation. They also had increased glucagon levels. Glucose uptake to most maternal tissues was ~2-fold greater in the hypoxic than normoxic dams. The alterations in maternal metabolism in hypoxia were associated with upregulation of hypoxia-inducible factor (HIF) target genes that serve, in turn, to increase glycolytic metabolism. We conclude that environmental hypoxia alters maternal metabolism by upregulating the HIF-pathway, and suggest that interventions that antagonize such changes in metabolism in high-altitude pregnancy may be helpful for preserving fetal growth.
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Registered trials
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