ArticleNature communications2018
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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46citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Identification of novel genome-wide pleiotropic associations with oral inflammatory traits.Molecular genetics and genomics : MGG · 2022Pooled it
- Periodontal Disease and Its Association withMicroorganisms · 2026Review
- Salivary Biomarkers of Inflammasome Activation in Unstable Periodontitis: A Case-Control Study.European journal of dentistry · 2026Article
- Genome-wide association study of periodontitis severity and progression.Journal of periodontology · 2026Article
- Inflammasome targeting for periodontitis prevention is sex dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Injectable responsive hydrogel with synergistic antibacterial and anti-inflammatory properties for enhanced periodontitis treatment.Journal of nanobiotechnology · 2025Article
- Gene variants, oxidative stress and inflammation in Colombian populationsBiomedica : revista del Instituto Nacional de Salud · 2025Article
- Review
- The Construction of Iodine-Doped Carbon Nitride as a Metal-Free Nanozyme for Antibacterial and Water Treatment.Nanomaterials (Basel, Switzerland) · 2024Article
- A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation.Nature genetics · 2024Article
- Integration of precision medicine into the dental care setting.Frontiers in dental medicine · 2024Article
- Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study.Frontiers in genetics · 2024Article
- Non-steroidal anti-inflammatory drug target gene associations with major depressive disorders: a Mendelian randomisation study integrating GWAS, eQTL and mQTL Data.The pharmacogenomics journal · 2023Article
- Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process.Frontiers in immunology · 2023Review
- Interferon activated gene 204 protects against bone loss in experimental periodontitis.Journal of periodontology · 2022Article
- NLRP3 inflammasome triggers interleukin-37 release from human monocytes.European journal of immunology · 2022Article
- Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease.Current osteoporosis reports · 2022Review
- Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health.Journal of clinical periodontology · 2022Article
- Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients.Meta gene · 2022Article
- Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium.International journal of oral science · 2021Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 2 countries.
Steven OffenbacherDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Yizu JiaoDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA. yizujiao@email.unc.edu.
Steven J KimDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Julie MarchesanDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Kevin L MossDepartment of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Li JingDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Kimon DivarisDepartment of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-1290-7251
Sompop BencharitDepartment of General Practice, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.
Cary S AglerOral and Craniofacial Health Sciences, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Thiago MorelliDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Shaoping ZhangDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Lu SunDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
William T SeamanLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Dale CowleyUNC Animal Models Core, University of North Carolina, Chapel Hill, NC, USA.
Silvana P BarrosDepartment of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
James D BeckDepartment of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Matthias MunzDepartment of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Berlin, Germany.
Arne S SchaeferDepartment of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Berlin, Germany.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USCharité - Universitätsmedizin Berlin · DEVirginia Commonwealth University · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MGenome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7MTraining Program for the Next Generation of Oral Health Researchers (NextGen)T90DE021986 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVERETT, ERIC T. · 2011 to 2017
$2.3MRole of IL-37 Genetic Variants in Modulating Innate Immune Resp to Periodontal PaR01DE023836 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARROS, SILVANA PEREIRA · 2014 to 2018
$1.9MGWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6MSYSTEMIC EFFECTS OF PERIODONTITISR01DE011551 · NIDCR · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BECK, JAMES D · 1996 to 2002
$1.2MGENOME-WIDE ASSOCIATION STUDY OF PERIODONTAL DISEASER01DE021418 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OFFENBACHER, STEVEN · 2011 to 2012
$658kThe Rolde of IL-37b from Plasma Cells in Periodontitis PathogenesisF32DE026688 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIAO, YIZU · 2016 to 2018
$114kNCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NIDCR NIH HHS F32 DE026688NIDCR NIH HHS R01 DE011551NIDCR NIH HHS R01 DE021418NIDCR NIH HHS R01 DE023836NIDCR NIH HHS T90 DE021986NIEHS NIH HHS P30 ES010126
Abstract
There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a GWAS for "high" gingival crevicular fluid IL-1β expression among 4910 European-American adults and identify association signals in the IL37 locus. rs3811046 at this locus (p = 3.3 × 10
Indexed as
Genetic VariationGenome-Wide Association StudyAmino Acid SequenceAnimalsChronic PeriodontitisDisease Models, AnimalFemaleGenetic LociGingival Crevicular FluidHaplotypesHEK293 CellsHumansInflammationInterleukin-1Interleukin-1betaLeukocytes, MononuclearIL37 protein, humanInterleukin-1Interleukin-1betaRNA, Messenger
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