ArticleNature communications2018
Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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22 citing papers in PubMed, 36 citations in OpenAlex.
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- Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer.International journal of molecular sciences · 2023Article
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- Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.Journal of experimental & clinical cancer research : CR · 2022Article
- Prevalence of Germline Sequence Variations Among Patients With Pancreatic Cancer in China.JAMA network open · 2022Article
- Introduction to DOK2 and its potential role in cancer.Physiological research · 2021Review
- Association of CMYC polymorphisms with hepatoblastoma risk.Translational cancer research · 2020Article
- Evaluation of polymorphisms in microRNA-binding sites and pancreatic cancer risk in Chinese population.Journal of cellular and molecular medicine · 2020Article
- ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility.Journal of oncology · 2020Article
- LIN28A gene polymorphisms modify neuroblastoma susceptibility: A four-centre case-control study.Journal of cellular and molecular medicine · 2020Article
- Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers.Translational oncology · 2019Article
- PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.Scientific reports · 2019Article
- A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population.Cancer medicine · 2019Article
- Additional data support the role ofAging · 2019Article
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Corrections and comments
- Erratum issued
Authors and funding
25 authors at 7 institutions in 1 country.
Jiang ChangDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.ORCID http://orcid.org/0000-0001-8551-9458
Jianbo TianDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Ying ZhuDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Rong ZhongDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Kan ZhaiDepartment of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Jiaoyuan LiDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Juntao KeDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
QiangQiang HanWuhan GeneCreate Biological Engineering Co., Ltd, 430075, Wuhan, China.
Jiao LouDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Wei ChenDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Beibei ZhuDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Na ShenDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Yi ZhangDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Yajie GongDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Yang YangDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Danyi ZouDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Xiating PengDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China.
Zhi ZhangDepartment of Chemotherapy and Radiotherapy, Tangshan Gongren Hospital, 063210, Tangshan, China.
Xuemei ZhangDepartment of Molecular Genetics, College of Life Science, North China University of Science and Technology, 063210, Tangshan, China.
Kun HuangTongji School of Pharmacy, Huazhong University of Science and Technology, 430030, Wuhan, China.
Ming YangShandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, 250117, Jinan, China.
Li WangDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 100730, Beijing, China.
Chen WuDepartment of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China. chenwu@cicams.ac.cn.ORCID http://orcid.org/0000-0003-4954-1011
Dongxin LinDepartment of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China. lindx@cicams.ac.cn.
Xiaoping MiaoDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, 430030, Wuhan, China. miaoxp@hust.edu.cn.ORCID http://orcid.org/0000-0002-6818-9722
Huazhong University of Science and Technology · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNShandong University · CNCapital Medical University · CNNorth China University of Science and Technology · CNTangshan Gongren Hospital · CNWuhan Institute of Bioengineering · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germline coding variants have not been systematically investigated for pancreatic ductal adenocarcinoma (PDAC). Here we report an exome-wide investigation using the Illumina Human Exome Beadchip with 943 PDAC cases and 3908 controls in the Chinese population, followed by two independent replicate samples including 2142 cases and 4697 controls. We identify three low-frequency missense variants associated with the PDAC risk: rs34309238 in PKN1 (OR = 1.77, 95% CI: 1.48-2.12, P = 5.35 × 10
Indexed as
Genetic Predisposition to DiseaseMutation RateAdenocarcinomaAsian PeopleCell ProliferationExomeHumansMutation, MissensePancreatic NeoplasmsPhosphorylationPolymorphism, Single NucleotideProtein Kinase CRisk FactorsSignal TransductionProtein Kinase Cprotein kinase N
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