ArticleNature communications2018
Reviving the Weizmann process for commercial n-butanol production.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- EngineeringACS synthetic biology · 2026Article
- Metabolic engineering of Parageobacillus thermoglucosidasius for thermophilic production of 1-butanol.AMB Express · 2025Article
- Comparative Metabolomics ofJournal of microbiology and biotechnology · 2025Article
- Toxic Effects of Butanol in the Plane of the Cell Membrane.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Valorization of milling byproducts and ergot-sclerotia-contaminated rye via clostridial ABE fermentation.Biotechnology for biofuels and bioproducts · 2024Article
- Chromosomal integration of the pSOL1 megaplasmid of Clostridium acetobutylicum for continuous and stable advanced biofuels production.Nature microbiology · 2024Article
- The potential of native and engineered Clostridia for biomass biorefining.Frontiers in bioengineering and biotechnology · 2024Review
- Design and thermodynamic analysis of a pathway enabling anaerobic production of poly-3-hydroxybutyrate inSynthetic and systems biotechnology · 2023Article
- Improvement of the Genome Editing Tools Based on 5FC/5FU Counter Selection inMicroorganisms · 2023Article
- Metabolic engineering of Thermoanaerobacterium aotearoense strain SCUT27 for biofuels production from sucrose and molasses.Biotechnology for biofuels and bioproducts · 2023Article
- Growth-coupled anaerobic production of isobutanol from glucose in minimal medium with Escherichia coli.Biotechnology for biofuels and bioproducts · 2023Article
- Current progress on engineering microbial strains and consortia for production of cellulosic butanol through consolidated bioprocessing.Microbial biotechnology · 2023Review
- Chromosomal engineering of inducible isopropanol- butanol-ethanol production inFrontiers in bioengineering and biotechnology · 2023Article
- Nutrient-Limited Operational Strategies for the Microbial Production of Biochemicals.Microorganisms · 2022Review
- First Stage of the Development of an Eco-Friendly Detergent Formulation for Efficient Removal of Carbonized Soil.Molecules (Basel, Switzerland) · 2022Article
- Identification of serine/threonine kinases that regulate metabolism and sporulation in Clostridium beijerinckii.Applied microbiology and biotechnology · 2022Article
- Genome Sequence ofMicroorganisms · 2022Article
- Molecular characterization of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum.Nature communications · 2022Article
- EstablishingApplied and environmental microbiology · 2022Article
- Physiological limitations and opportunities in microbial metabolic engineering.Nature reviews. Microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Developing a commercial process for the biological production of n-butanol is challenging as it needs to combine high titer, yield, and productivities. Here we engineer Clostridium acetobutylicum to stably and continuously produce n-butanol on a mineral media with glucose as sole carbon source. We further design a continuous process for fermentation of high concentration glucose syrup using in situ extraction of alcohols by distillation under low pressure and high cell density cultures to increase the titer, yield, and productivity of n-butanol production to the level of 550 g/L, 0.35 g/g, and 14 g/L/hr, respectively. This process provides a mean to produce n-butanol at performance levels comparable to that of corn wet milling ethanol plants using yeast as a biocatalyst. It may hold the potential to be scaled-up at pilot and industrial levels for the commercial production of n-butanol.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.