Evidence map›Paper›PMID 30206183›Full record

ArticleTobacco control2018

Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke.

Pooneh Nabavizadeh, Jiangtao Liu, Christopher M Havel, Sharina Ibrahim, Ronak Derakhshandeh, Peyton Jacob Iii, Matthew L Springer

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Association between current heated tobacco product use and incident hypertension: A nationwide real-world cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  6. Article
  7. The respiratory health effects of heated tobacco product aerosols in a primary human airway epithelial cell model.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  8. Review
  9. Article
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  11. Review
  12. Review
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  15. Observational
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  18. Review
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pooneh NabavizadehCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Jiangtao LiuCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Christopher M HavelDivision of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, San Francisco, California, USA.
Sharina IbrahimDivision of Cardiology, University of California, San Francisco, San Francisco, California, USA.
Ronak DerakhshandehCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Peyton Jacob IiiDivision of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, San Francisco, California, USA.
Matthew L SpringerCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · US

Funding

Training and Education p489-500P50CA180890 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2013 to 2018
$20.5M
PROJECT 5: IMPACT OF CHANGING TOBACCO PRODUCT USE ON HEALTHCARE COSTS FOR GENERAL AND VULNERABLE POPULATIONSU54HL147127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2018 to 2022
$20.4M
Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ST.HELEN, GIDEON · 1999 to 2024
$17.1M
Measuring relative cardiovascular health risks of inhaled tobacco productsR01HL120062 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPRINGER, MATTHEW LAWRENCE · 2014 to 2018
$2.8M
NCI NIH HHS P50 CA180890NHLBI NIH HHS R01 HL120062NHLBI NIH HHS U54 HL147127NIDA NIH HHS P30 DA012393
6 · The paper itself

Abstract

backgroundHeated tobacco products (also called 'heat-not-burn' products) heat tobacco at temperatures below that of combustion, causing nicotine and other compounds to aerosolise. One such product, IQOS from Philip Morris International, is being marketed internationally with claims of harm reduction. We sought to determine whether exposure to IQOS aerosol impairs arterial flow-mediated dilation (FMD), a measure of vascular endothelial function that is impaired by tobacco smoke.

methodsWe exposed anaesthetised rats (n=8/group) via nose cone to IQOS aerosol from single HeatSticks, mainstream smoke from single Marlboro Red cigarettes or clean air for a series of consecutive 30 s cycles over 1.5-5 min. Each cycle consisted of 15 or 5 s of exposure followed by removal from the nose cone. We measured pre-exposure and postexposure FMD, and postexposure serum nicotine and cotinine.

resultsFMD was impaired comparably by ten 15 s exposures and ten 5 s exposures to IQOS aerosol and to cigarette smoke, but not by clean air. Serum nicotine levels were similar to plasma levels after humans have smoked one cigarette, confirming that exposure conditions had real-world relevance. Postexposure nicotine levels were ~4.5-fold higher in rats exposed to IQOS than to cigarettes, despite nicotine being measured in the IQOS aerosol at ~63% the amount measured in smoke. When IQOS exposure was briefer, leading to comparable serum nicotine levels to the cigarette group, FMD was still comparably impaired.

conclusionsAcute exposures to IQOS aerosol impairs FMD in rats. IQOS use does not necessarily avoid the adverse cardiovascular effects of smoking cigarettes.

Indexed as

AerosolsAnimalsArteriesCotinineMaleNicotineRatsSmokeTobacco ProductsVasodilationAerosolsCotinineNicotineSmokeelectronic nicotine delivery devicesharm reductionnicotinenon-cigarette tobacco productssmoking caused disease

Identifiers

PMID30206183
PMCPMC6202192
OpenAlexW2890661630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.