Evidence map›Paper›PMID 30206169›Full record

ArticlemBio2018

Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness.

Rishi R Trivedi, John A Crooks, George K Auer, Joel Pendry, Ilona P Foik, Albert Siryaporn, Nicholas L Abbott, Zemer Gitai, Douglas B Weibel

Abstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. DadY (PA5303) is required for fitness ofMicrobial cell (Graz, Austria) · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Constructing and deconstructing the bacterial cell wall.Protein science : a publication of the Protein Society · 2020
    Review
  18. Mechanical stress compromises multicomponent efflux complexes in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rishi R TrivediDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
John A CrooksDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
George K AuerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joel PendryDepartment of Chemical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ilona P FoikDepartment of Physics & Astronomy, University of California, Irvine, Irvine, California, USA.
Albert SiryapornDepartment of Physics & Astronomy, University of California, Irvine, Irvine, California, USA.
Nicholas L AbbottDepartment of Chemical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Zemer GitaiDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Douglas B WeibelDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA douglas.weibel@wisc.edu.

Funding

Mechano-microbiology: how physical forces control bacterial-host interactionsDP1AI124669 · NIAID · PRINCETON UNIVERSITY · PI GITAI, ZEMER · 2015 to 2019
$4.0M
Revisiting the bacterial cell wall as a target for new antibioticsDP2OD008735 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI WEIBEL, DOUGLAS BENJAMIN · 2011 to 2011
$2.3M
NIAID NIH HHS DP1 AI124669NIH HHS DP2 OD008735
6 · The paper itself

Abstract

The stiffness of bacteria prevents cells from bursting due to the large osmotic pressure across the cell wall. Many successful antibiotic chemotherapies target elements that alter mechanical properties of bacteria, and yet a global view of the biochemistry underlying the regulation of bacterial cell stiffness is still emerging. This connection is particularly interesting in opportunistic human pathogens such as

Indexed as

ElasticityAlanineAlanine DehydrogenaseCell WallGene DeletionGenes, BacterialMetabolic Networks and PathwaysPeptidoglycanPseudomonas aeruginosaAlanineAlanine DehydrogenasePeptidoglycancell stiffnesscell wallDadAmechanical genomicsPseudomonas aeruginosa

Identifiers

PMID30206169
PMCPMC6134093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.