ArticleJournal of the American Society of Nephrology : JASN2018
Assessment of Perfusion and Oxygenation of the Human Renal Cortex and Medulla by Quantitative MRI during Handgrip Exercise.
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07019519 (Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- GLP-1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading.Journal of the American Heart Association · 2023Trial
- Reproducibility of Splanchnic Blood Flow Measured Using Phase-Contrast MRI.NMR in biomedicine · 2026Observational
- Measurement of renal cortex perfusion: A direct comparison of arterial spin labelling magnetic resonance imaging and [Magnetic resonance in medicine · 2025Article
- Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation.Renal failure · 2024Article
- Physiological confounders of renal blood flow measurement.Magma (New York, N.Y.) · 2024Review
- Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes.Clinical kidney journal · 2022Article
- Monitoring of renal perfusion.Intensive care medicine · 2022Article
- Contrast-Enhanced Ultrasonography Enables the Detection of a Cold Pressor Test-Induced Increase in Renal Microcirculation in Healthy Participants.Frontiers in cardiovascular medicine · 2022Article
- Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: A randomised, double-blind, placebo-controlled crossover trial.EClinicalMedicine · 2021Article
- Hip Position Acutely Affects Oxygenation and Perfusion of Kidney Grafts as Measured by Functional Magnetic Resonance Imaging Methods-The Bent Knee Study.Frontiers in medicine · 2021Article
- The Cardiovascular Stress Response as Early Life Marker of Cardiovascular Health: Applications in Population-Based Pediatric Studies-A Narrative Review.Pediatric cardiology · 2020Review
- The utility of magnetic resonance imaging for noninvasive evaluation of diabetic nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Article
- Consensus-based technical recommendations for clinical translation of renal ASL MRI.Magma (New York, N.Y.) · 2020Article
- Assessment of acute bone loading in humans using [European journal of nuclear medicine and molecular imaging · 2019Article
- Human renal response to furosemide: Simultaneous oxygenation and perfusion measurements in cortex and medulla.Acta physiologica (Oxford, England) · 2019Article
- Renal Perfusion and Renal Nerve Activity.Journal of the American Society of Nephrology : JASN · 2019Article
Corrections and comments
- Commented on byAuthors' Reply.2019
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- Commented on byAuthors' Reply.2019
- Erratum issuedErratum.2019
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity.
methodsTo monitor medullary and cortical oxygenation under handgrip exercise-reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise. We used phase-contrast MRI to measure RAF, arterial spin labeling to measure perfusion, and both changes in transverse relaxation time (T
resultsHandgrip exercise induced a significant decrease in RAF. In the renal medulla, this was accompanied by an increase of oxygenation (reflected by an increase in T
conclusionsRenal MRI measurements in response to handgrip exercise were consistent with a sympathetically mediated decrease in RAF. In the renal medulla, oxygenation increased despite a reduction in perfusion, which we interpreted as the result of decreased GFR and a subsequently reduced reabsorptive workload. Our results further indicate that the renal flow response's sensitivity to sympathetic activation is correlated with resting BP, even within a normotensive range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.