Evidence map›Paper›PMID 30206134›Full record

ArticleBioscience reports2018

Systemic angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep.

Christopher J Charles, David L Jardine, Miriam T Rademaker, A Mark Richards

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher J CharlesChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.
David L JardineChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand david.jardine@cdhb.govt.nz.
Miriam T RademakerChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.
A Mark RichardsChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.
University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While it is well established that centrally injected angiotensin II (Ang II) has potent actions on sympathetic nervous activity (SNA), it is less clear whether peripheral Ang II can immediately stimulate SNA. In particular, the contribution of cardiac sympathetic nerve activity (CSNA) to the acute pressor response is unknown. We therefore examined the effect of incremental doses of intravenous Ang II (3, 6, 12, 24, and 48 ng/kg/min each for 30 min) on CSNA in eight conscious sheep. Ang II infusions progressively increased plasma Ang II up to 50 pmol/l above control levels in dose-dependent fashion (

Indexed as

Administration, IntravenousAngiotensin IIAnimalsArterial PressureAutonomic Nerve BlockBlood PressureCatecholaminesCoronary VesselsDose-Response Relationship, DrugHeartHeart RatePressoreceptorsSheepSympathetic Nervous SystemAngiotensin IICatecholaminesangiotensinsblood pressuresympathetic nervous system

Identifiers

PMID30206134
PMCPMC6435558
OpenAlexW2891789771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.