Evidence map›Paper›PMID 30206120›Full record

ArticleThe Journal of biological chemistry2018

Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.

Borja Ochoa-Lizarralde, Yong-Guang Gao, Alexander N Popov, Valeria R Samygina, Xiuhong Zhai, Shrawan K Mishra, Ivan A Boldyrev, Julian G Molotkovsky, Dhirendra K Simanshu, Dinshaw J Patel and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets.International journal of molecular sciences · 2019
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Borja Ochoa-LizarraldeFrom the Structural Biology Unit of CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Spain.
Yong-Guang Gaothe Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Alexander N Popovthe European Synchrotron Radiation Facility, 38043 Grenoble, France.
Valeria R SamyginaFrom the Structural Biology Unit of CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Spain.ORCID 0000-0002-1528-5972
Xiuhong Zhaithe Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Shrawan K Mishrathe Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Ivan A Boldyrevthe Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia, and.
Julian G Molotkovskythe Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia, and.
Dhirendra K Simanshuthe Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.ORCID 0000-0002-9717-4618
Dinshaw J Patelthe Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Rhoderick E Brownthe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, reb@umn.edu.ORCID 0000-0002-7337-3604
Lucy MalininaFrom the Structural Biology Unit of CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Spain, lucy@hi.umn.edu.ORCID 0000-0001-7973-1831
University of Minnesota · USCIC bioGUNE · ESInstitute of Bioorganic Chemistry · RUMemorial Sloan Kettering Cancer Center · USEuropean Synchrotron Radiation Facility · FR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
GLYCOLIPID TRANSFER--REGULATION BY MEMBRANE INTERFACESR01GM045928 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BROWN, RHODERICK E · 1992 to 2014
$4.8M
The functional role of the cPLA2alpha/C1P interaction in sepsis resolutionR01HL125353 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RHODERICK E, CHALFANT, CHARLES E. · 2014 to 2018
$4.0M
MOLECULAR BASIS OF GLYCOSPHINGOLIPID BINDING SPECIFICITYR01CA121493 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PATEL, DINSHAW J · 2006 to 2010
$1.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA121493NHLBI NIH HHS R01 HL125353NIGMS NIH HHS R01 GM045928
6 · The paper itself

Abstract

The glycolipid transfer protein (GLTP) fold defines a superfamily of eukaryotic proteins that selectively transport sphingolipids (SLs) between membranes. However, the mechanisms determining the protein selectivity for specific glycosphingolipids (GSLs) are unclear. Here, we report the crystal structure of the GLTP homology (GLTPH) domain of human 4-phosphate adaptor protein 2 (FAPP2) bound with

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SequenceCarrier ProteinsCrystallography, X-RayGolgi ApparatusHumansMolecular Sequence DataMultigene FamilyProtein ConformationSequence AlignmentSphingolipidsAdaptor Proteins, Signal TransducingCarrier Proteinslipid transfer proteinPLEKHA8 protein, humanSphingolipids4-phosphate-adaptor-protein-2FAPP2lipid-protein interactionnonvesicular lipid transportprotein complexprotein familyprotein structuresphingolipidtransportX-ray crystallography

Identifiers

PMID30206120
PMCPMC6204895
OpenAlexW2891533071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.