Evidence map›Paper›PMID 30206098›Full record

ArticleBlood advances2018

Is a matched unrelated donor search needed for all allogeneic transplant candidates?

Stefan O Ciurea, Maria Cecilia Borges Bittencourt, Denái R Milton, Kai Cao, Piyanuch Kongtim, Gabriela Rondon, Julianne Chen, Marina Konopleva, Jorge M Ramos Perez, Mohammed F El Shazly and 12 more

Abstract read
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Barriers to Hematopoietic Cell Transplantation for Adults in the United States: A Systematic Review with a Focus on Age.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Pooled it
  2. Trial
  3. Outcomes of Related and Unrelated Donor Searches Among Patients with Primary Immunodeficiency Diseases Referred for Allogeneic Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Stefan O CiureaDepartment of Stem Cell Transplantation and Cellular Therapy.
Maria Cecilia Borges BittencourtDepartment of Stem Cell Transplantation and Cellular Therapy.
Denái R MiltonDepartment of Biostatistics.
Kai CaoDepartment of Pathology, and.
Piyanuch KongtimDepartment of Stem Cell Transplantation and Cellular Therapy.
Gabriela RondonDepartment of Stem Cell Transplantation and Cellular Therapy.
Julianne ChenDepartment of Stem Cell Transplantation and Cellular Therapy.
Marina KonoplevaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jorge M Ramos PerezDepartment of Stem Cell Transplantation and Cellular Therapy.
Mohammed F El ShazlyDepartment of Stem Cell Transplantation and Cellular Therapy.
Majdi AljadayehDepartment of Stem Cell Transplantation and Cellular Therapy.
Michele AlvarezDepartment of Stem Cell Transplantation and Cellular Therapy.
Jin ImDepartment of Stem Cell Transplantation and Cellular Therapy.
Gheath Al-AtrashDepartment of Stem Cell Transplantation and Cellular Therapy.
Rohtesh MehtaDepartment of Stem Cell Transplantation and Cellular Therapy.
Uday PopatDepartment of Stem Cell Transplantation and Cellular Therapy.
Qaiser BashirDepartment of Stem Cell Transplantation and Cellular Therapy.
Betul OranDepartment of Stem Cell Transplantation and Cellular Therapy.
Chitra M HosingDepartment of Stem Cell Transplantation and Cellular Therapy.
Issa F KhouriDepartment of Stem Cell Transplantation and Cellular Therapy.
Partow KebriaeiDepartment of Stem Cell Transplantation and Cellular Therapy.
Richard E ChamplinDepartment of Stem Cell Transplantation and Cellular Therapy.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Donor availability for allogeneic transplantation remains an important factor in determining outcomes of a successful transplant. We examined outcomes of 242 patients treated over 3 years who had a matched unrelated donor (MUD) search at our institution. One hundred sixty patients (66%) had a 10 of 10 MUD identified, and 85 (53%) proceeded to MUD transplantation. White patients and those with common haplotypes were more likely to have a MUD identified (odds ratio [OR], 7.4 [

Indexed as

Histocompatibility TestingAdolescentAdultAgedChildHaplotypesHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansMiddle AgedRemission InductionRisk FactorsSurvival AnalysisTransplantation, HaploidenticalTransplantation, HomologousUnrelated Donors

Identifiers

PMID30206098
PMCPMC6134218

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.