Evidence map›Paper›PMID 30206085›Full record

ArticleBMJ open2018

Are noise and air pollution related to the incidence of dementia? A cohort study in London, England.

Iain M Carey, H Ross Anderson, Richard W Atkinson, Sean D Beevers, Derek G Cook, David P Strachan, David Dajnak, John Gulliver, Frank J Kelly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  10. Traffic Noise and Mental Health: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
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  13. Air Pollution and Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2019
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iain M CareyPopulation Health Research Institute, St George's, University of London, London, UK.ORCID 0000-0003-1099-8460
H Ross AndersonPopulation Health Research Institute, St George's, University of London, London, UK.
Richard W AtkinsonPopulation Health Research Institute, St George's, University of London, London, UK.
Sean D BeeversMRC-PHE Centre for Environment and Health, King's College London, London, UK.
Derek G CookPopulation Health Research Institute, St George's, University of London, London, UK.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, UK.
David DajnakMRC-PHE Centre for Environment and Health, King's College London, London, UK.
John GulliverUK Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, Imperial College, London, UK.
Frank J KellyMRC-PHE Centre for Environment and Health, King's College London, London, UK.

Funding

Department of Health NE/I007806/1Department of Health NE/I00789X/1Department of Health NE/I008039/1Medical Research Council MR/L01341X/1Wellcome Trust
6 · The paper itself

Abstract

objectiveTo investigate whether the incidence of dementia is related to residential levels of air and noise pollution in London.

designRetrospective cohort study using primary care data.

setting75 Greater London practices.

participants130 978 adults aged 50-79 years registered with their general practices on 1 January 2005, with no recorded history of dementia or care home residence. PRIMARY AND SECONDARY OUTCOME MEASURES: A first recorded diagnosis of dementia and, where specified, subgroups of Alzheimer's disease and vascular dementia during 2005-2013. The average annual concentrations during 2004 of nitrogen dioxide (NO

results2181 subjects (1.7%) received an incident diagnosis of dementia (39% mentioning Alzheimer's disease, 29% vascular dementia). There was a positive exposure response relationship between dementia and all measures of air pollution except O

conclusionsWe have found evidence of a positive association between residential levels of air pollution across London and being diagnosed with dementia, which is unexplained by known confounding factors.

Indexed as

Air PollutionAlzheimer DiseaseDementia, VascularEnvironmental ExposureNoiseAgedFemaleHumansLondonMaleMiddle AgedNitrogen DioxideParticulate MatterPrimary Health CareResidence CharacteristicsRisk FactorsNitrogen DioxideParticulate MatterVehicle Emissionsair pollutionalzheimer’s diseasedementianoiseprimary care

Identifiers

PMID30206085
PMCPMC6144407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.