Evidence map›Paper›PMID 30206073›Full record

ArticleBMJ open2018

Association between serum magnesium concentration and metabolic syndrome, diabetes, hypertension and hyperuricaemia in knee osteoarthritis: a cross-sectional study in Hunan Province, China.

Yilun Wang, Jie Wei, Chao Zeng, Tuo Yang, Hui Li, Yang Cui, Dongxing Xie, Bei Xu, Zhichen Liu, Jiatian Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. American journal of translational research · 2020
    Article
  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yilun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jie WeiHealth Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tuo YangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hui LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang CuiInternational Medical Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dongxing XieDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bei XuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhichen LiuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiatian LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shide JiangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guanghua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine the associations between serum magnesium (Mg) concentration with the prevalence of metabolic syndrome (MetS), diabetes mellitus (DM), hypertension (HP) and hyperuricaemia (HU) in patients with radiographic knee osteoarthritis (OA).

methodsThe present study was conducted at the Health Management Center of Xiangya Hospital. Radiographic OA was evaluated for patients aged over 40 years with basic characteristics and blood biochemical assessment. Serum Mg concentration was measured using the chemiluminescence method. MetS, DM, HP and HU were diagnosed based on standard protocols. The associations between serum Mg concentration with MetS, DM, HP and HU were evaluated by conducting multivariable adjusted logistic regression.

resultsA total of 962 patients with radiographic knee OA were included. Compared with the lowest quintile, the multivariable adjusted ORs and related 95% CIs of DM were 0.40 (95% CI 0.23 to 0.70, p=0.001), 0.33 (95% CI 0.18 to 0.60, p<0.001), 0.27 (95% CI 0.14 to 0.52, p<0.001) and 0.22 (95% CI 0.11 to 0.44, p<0.001) in the second, third, fourth and highest quintiles of serum Mg, respectively (p for trend <0.001); the multivariable adjusted ORs of HU were 0.33 (95% CI 0.19 to 0.59, p<0.001), 0.52 (95% CI 0.30 to 0.91, p=0.022) and 0.39 (95% CI 0.22 to 0.70, p=0.001) in the third, fourth and highest quintiles of serum Mg, respectively (p for trend <0.001); and the multivariable adjusted ORs of MetS were 0.59 (95% CI 0.36 to 0.94, p=0.027) in the second and 0.56 (95% CI 0.34 to 0.93, p=0.024) in the highest quintiles of serum Mg. However, the inverse association between serum Mg and the prevalence of MetS was non-linear (p for trend=0.067). There was no significant association between serum Mg and HP in patients with OA.

conclusionsThe serum Mg concentration was inversely associated with the prevalence of MetS, DM and HU in patients with radiographic knee OA. LEVEL OF EVIDENCE: Level III, cross-sectional study.

Indexed as

ChinaComorbidityCross-Sectional StudiesDiabetes MellitusFemaleHumansHypertensionHyperuricemiaMagnesiumMaleMetabolic SyndromeMiddle AgedOsteoarthritis, KneePrevalenceMagnesiumdiabeteshypertensionhyperuricemiamagnesiummetabolic syndromeosteoarthritis

Identifiers

PMID30206073
PMCPMC6144480
OpenAlexW2891891917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.