Evidence map›Paper›PMID 30206065›Full record

ArticleBMJ case reports2018

Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use.

Ashley L Lukefahr, Sean McEvoy, Chelsea Alfafara, Janet L Funk

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Turmeric-Associated Drug-Induced Liver Injury.ACG case reports journal · 2022
    Article
  11. Hepatotoxicity due to herbal dietary supplements: Past, present and the future.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Turmeric-Induced Hepatotoxicity: Report of 2 Cases.International medical case reports journal · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Frontiers in pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashley L LukefahrDepartment of Pathology, University of Arizona, Tucson, Arizona, USA.
Sean McEvoyDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Chelsea AlfafaraDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Janet L FunkDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.ORCID http://orcid.org/0000-0002-9826-5407
University of Arizona · US

Funding

Exploiting the Tumor Microenvironment to Block Breast Cancer Bone MetastasisR01CA174926 · NCI · UNIVERSITY OF ARIZONA · PI FUNK, JANET L · 2014 to 2018
$1.6M
Curcuma longa L. in Rheumatoid Arthritis (CLaRA): Clinical Planning StudyR34AT007837 · NCCIH · UNIVERSITY OF ARIZONA · PI FUNK, JANET L · 2013 to 2015
$737k
NCCIH NIH HHS R34 AT007837NCI NIH HHS R01 CA174926
6 · The paper itself

Abstract

Turmeric dietary supplement sales, which accounted for US$69 million in spending in 2016, have been increasing exponentially in the USA, making this one of the most popular botanical supplements sold in the USA. Herbal supplement use, which is generally regarded as safe by consumers, is not usually reported to healthcare providers. We reported here on a case of autoimmune hepatitis, occurring in a 71-year-old woman taking turmeric dietary supplements for the maintenance of cardiovascular health, which resolved rapidly following discontinuation of the turmeric supplements. Of particular note, turmeric use was not documented in the patient's medical records and the potential causative role of the turmeric supplementation was ultimately identified by the patient rather than the healthcare providers. To our knowledge, this is the first documented report of turmeric supplement-induced autoimmune hepatitis.

Indexed as

AgedCurcumaDiagnosis, DifferentialDietary SupplementsFemaleHepatitis, AutoimmuneHumansLiverLiver Function TestsWithholding Treatmentcomplementary medicinecontraindications and precautionsgastrointestinal systemhealthcare improvement and patient safetyhepatitis other

Identifiers

PMID30206065
PMCPMC6144106
OpenAlexW2891363047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.